Production of Proteinase with Plasmin-Like and Prekallikrein Activating Activity by the Micromycete Aspergillus terreus

The effect of nitrogen sources in the fermentation medium and the cultivation conditions on the production of proteinases with plasmin-like and prekallikrein activation activity by micromycete Aspergillus terreus 2 was investigated. The highest secretion of proteinases was achieved when the micromyc...

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Published inApplied biochemistry and microbiology Vol. 54; no. 2; pp. 206 - 210
Main Authors Zvonareva, E. S., Osmolovskiy, A. A., Kreier, V. G., Baranova, N. A., Kotova, I. B., Egorov, N. S.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.03.2018
Springer Nature B.V
Subjects
Aspergillus terreus
Biochemistry
Biomedical and Life Sciences
Cultivation
Fermentation
Fibrin
Fibrinogen
Life Sciences
Medical Microbiology
Microbiology
Nitrogen sources
Plasmin
Proteinase
Secretion
prekallikrein activators
fibrinolytic enzymes
proteinase
plasmin-like activity
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Summary:The effect of nitrogen sources in the fermentation medium and the cultivation conditions on the production of proteinases with plasmin-like and prekallikrein activation activity by micromycete Aspergillus terreus 2 was investigated. The highest secretion of proteinases was achieved when the micromycete was cultivated on a medium containing both amine- and mineral nitrogen sources at an initial pH of 5.5 and at 28°С. It was established that the extracellular micromycete proteinases are equally capable of hydrolyzing fibrin and fibrinogen.
ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683818020151