New promising porphyrazine-based agents for optical theranostics of cancer

New porphyrazine bases containing peripheral benzyloxyphenyl groups have been synthesized by the template method. The procedure includes condensation of aromatic aldehydes with malononitrile, transformation of arylmethylidenemalononitriles to arylethenetricarbonitriles, template assembly of porphyra...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 87; no. 3; pp. 479 - 484
Main Authors Lermontova, S. A., Grigor’ev, I. S., Peskova, N. N., Ladilina, E. Yu, Balalaeva, I. V., Klapshina, L. G., Boyarskii, V. P.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.03.2017
Springer Nature
Springer Nature B.V
Subjects
Aldehydes
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Luminescence
Malononitrile
Optical properties
Physical Sciences
Science & Technology
Ytterbium
template synthesis
ytterbium complexes
porphyrazines
photosensitizers
optical theranostic agents
optical intracellular viscosity probes
PHOTODYNAMIC THERAPY
VISCOSITY
photo-sensitizers
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Summary:New porphyrazine bases containing peripheral benzyloxyphenyl groups have been synthesized by the template method. The procedure includes condensation of aromatic aldehydes with malononitrile, transformation of arylmethylidenemalononitriles to arylethenetricarbonitriles, template assembly of porphyrazine macrocycle on bis(indenyl)ytterbium(II) complex, and removal of the central metal ion. Luminescence properties of the synthesized porphyrazines and their dependence on the viscosity of the medium were studied, and the light and dark toxicities of the porphyrazines have been estimated. The obtained results suggest the possibility of using these porphyrazines as optical theranostic agents of new generation.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363217030173