Association between SNPs in AdipoQ, +45 T > G and +276 G > T, and adiponectin levels in the Korean Chinese population in Yanbian, China

• Published in: International journal of diabetes in developing countries Vol. 36; no. 4; pp. 401 - 406
• Main Authors: Sheng, Tianxin, Cui, Zhengwei, Zhou, Wenjing, Li, Qingji, Hu, Qiufang, Jin, Yanhua, Zhang, Zibo, Jin, Yan, Jin, Xiongji, Yang, Kangjuan
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.12.2016; Springer Nature B.V
• Subjects: Adiponectin; Alleles; Body fat; Cholesterol; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Family Medicine; Fasting; General Practice; Genotype & phenotype; Health Administration; High density lipoprotein; Homeostasis; Insulin; Laboratory testing; Linkage disequilibrium; Low density lipoprotein; Males; Medicine; Medicine & Public Health; Original Article; Risk factors; Sex differences; Single-nucleotide polymorphism; Statistical analysis; China; Type 2 diabetes; Hypoadiponectinemia; Adiponectin
• ISSN: 0973-3930; 1998-3832
• DOI: 10.1007/s13410-015-0353-9

This study investigated the association between single nucleotide polymorphisms (SNPs) in AdipoQ , +45 T > G and +276 G > T, and adiponectin levels in the Korean Chinese population in Yanbian, China. A total of 329 subjects were involved in this study, including 178 female and 151 male individuals. All of them are ethnic Koreans living in Yanbian, aged from 31 to 70, and 58 % of them were diagnosed with type 2 diabetes (T2D). Items tested and calculated include total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), body fat percentage (BF%), fasting plasma insulin (FPI), plasma adiponectin (PA), and homeostasis model assessment of insulin resistance (HOMA-IR). SNPs were screened with the method of SNaPshot. P  < 0.05 was defined as the statistically significant threshold. Results include the following: (1) PA levels in the T2D group are much lower than those in the normal group ( P  < 0.001); (2) the distribution of genotypes of SNPs +45 T > G and +276 G > T was determined to be in Hardy-Weinberg equilibrium ( P  > 0.05) and complete linkage disequilibrium (| D ′| = 1.0); (3) PA levels in females are much higher than those in males no matter which group they belong to (normal or T2D group) ( P  = 0.004 and P  = 0.018); (4) PA levels are higher in the individuals with +45G as a dominant allele than those in individuals with homozygous genotype TT at locus +45 in the normal group ( P  = 0.037); and (5) of SNPs +45 T > G and +276 G > T, no risk factor of genotype or allele was found ( P  > 0.05). Three conclusions can be drawn: (1) PA levels are lower in T2D patients than in normal persons; (2) PA levels are higher in females than in males; (3) PA levels are higher for normal individuals with +45G allele than those with homozygous TT genotype at locus +45 in AdipoQ .