The Different Effects of Metal Ions on the Synthesis of Macroacyclic Compounds: X-ray Crystal Structure, Theoretical Studies, Antibacterial and Antifungal Activities
In this work, we have been involved studying the synthesis of some new macroacyclic complexes I – VIII , so we tried to get propoesed results in all cases but in the case of compound I , according to X-ray crystal structure, the product is a protonated Schiff base. By the reaction of a 1 : 1 (metal...
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Published in | Russian journal of coordination chemistry Vol. 45; no. 2; pp. 142 - 153 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Moscow
Pleiades Publishing
01.02.2019
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | In this work, we have been involved studying the synthesis of some new macroacyclic complexes
I
–
VIII
, so we tried to get propoesed results in all cases but in the case of compound
I
, according to X-ray crystal structure, the product is a protonated Schiff base. By the reaction of a 1 : 1 (metal : ligand) stoichiometry of two known Schiff base ligands, 1,2-bis(2-((2-hydroxy ethylimino)methyl)phenoxy)ethane (H
2
L
1
) or 1,3-bis(2-((2-hydroxyethylimino)methyl) phenoxy)propane (H
2
L
2
) and appropriate metal salts in methanol in the case of Ni
2+
, Cu
2+
and Co
2+
, macroacyclic complexes were prepared. When using Mn
2+
only protonated Schiff base ligands is the final product. All compounds were characterized by microanalysis and IR spectroscopy, whereas compound
I
was also characterized by single crystal X-ray. The X-ray structure of compound
I
showed that both protonated imines are neutralized by two perchlorate ions. Computational calculations of relevant complexes are done by using one of the hybrid density functional theories which are a B3LYP method with 6-31G(d) basis set in a vacuum. Also, the synthesized compounds were screened for their antibacterial activities against nine bacterial strains and showed antibacterial effects. These complexes also showed antifungal effects on two species of Candida. |
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ISSN: | 1070-3284 1608-3318 |
DOI: | 10.1134/S1070328419020064 |