Biocompatible nanoclusters of O-carboxymethyl chitosan-coated Fe3O4 nanoparticles: synthesis, characterization and magnetic heating efficiency

• Published in: Journal of materials science Vol. 53; no. 12; pp. 8887 - 8900
• Main Authors: Linh, P. H., Chien, N. V., Dung, D. D., Nam, P. H., Hoa, D. T., Anh, N. T. N., Hong, L. V., Phuc, N. X., Phong, P. T.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2018; Springer Nature B.V
• Subjects: Biocompatibility; Characterization and Evaluation of Materials; Chemical Routes to Materials; Chemical synthesis; Chemistry and Materials Science; Chitosan; Classical Mechanics; Clusters; Crystallography and Scattering Methods; Heating; Hyperthermia; Iron oxides; Magnetic properties; Magnetic saturation; Magnetism; Materials Science; Nanoclusters; Nanoparticles; Polymer Sciences; Solid Mechanics; Toxicity; Magnetic Heating; Hydrodynamic Size; Large Magnetic Clusters; Alternating Magnetic Field (AMF); Core Shell Nanoclusters
• ISSN: 0022-2461; 1573-4803
• DOI: 10.1007/s10853-018-2180-0

In this work, we developed a polymer encapsulation of Fe 3 O 4 nanoparticles as a core–shell nanocluster with different sizes to investigate the cluster structure effect on their magnetic properties and magnetic heating behavior. Well-dispersed nanoclusters of O -carboxymethyl chitosan-coated Fe 3 O 4 nanoparticles were synthesized by microwave-assisted co-precipitation. The cluster sizes were tunable by varying the concentration of polymers used during synthesis. Nanoclusters present superparamagnetic behavior at room temperature with a reduction in saturation magnetization as a consequence of coating layer. The shift of blocking temperature to the higher value with increasing clusters size shows the stronger magnetic interaction in larger magnetic clusters. In a low alternating magnetic field with frequency of 178 Hz and amplitude of 103 Oe, nanoclusters offer a high heating efficiency. A maximum specific absorption rate of 204 W/g is observed in the sample with hydrodynamic size of 53 nm. In vitro cytotoxicity analysis performed on HeLa cells verified that nanoclusters show a good biocompatibility and can be an excellent candidate for applications in hyperthermia cancer treatment.