A synthetic fragment 60–70 of the receptor for advanced glycation end products exhibits a therapeutic effect in an animal model of Alzheimer’s disease

Six synthetic peptides overlapping a fragment 60–76 of the receptor for advanced glycation end products (RAGE) were studied on a protective effect on spatial memory of animals in the experimental model of Alzheimer’s disease. It was shown that only a peptide corresponding to the fragment 60–70 of RA...

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Bibliographic Details
Published inRussian journal of bioorganic chemistry Vol. 43; no. 2; pp. 150 - 154
Main Authors Koroev, D. O., Volpina, O. M., Volkova, T. D., Kamynina, A. V., Filatova, M. P., Balasanyants, S. M., Samokhin, A. N., Bobkova, N. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.03.2017
Springer Nature B.V
Subjects
Animal memory
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Fragmentation
Life Sciences
Memory tasks
Organic Chemistry
Peptides
Spatial analysis
beta-amyloid
synthetic peptides
Alzheimer’s disease
receptor for advanced glycation end products
intranasal administration
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Summary:Six synthetic peptides overlapping a fragment 60–76 of the receptor for advanced glycation end products (RAGE) were studied on a protective effect on spatial memory of animals in the experimental model of Alzheimer’s disease. It was shown that only a peptide corresponding to the fragment 60–70 of RAGE exhibits a therapeutic activity. Intranasal administration of this peptide into bulbectomized mice, which develop neurodegenerative features of the Alzheimer type, completely protects animal memory. Thus, it was found that the N -terminal region (60–70) within the peptide sequence 60–76 of RAGE is responsible for the revealed protective effect. The synthetic peptide RAGE-(60–70) could be the basis for the development of a new drug for the treatment of Alzheimer’s disease.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162017020066