Reactivity of skin microcirculation as a biomarker of cardiovascular events. Pilot study

• Published in: Clinical hemorheology and microcirculation Vol. 78; no. 3; pp. 247 - 257
• Main Authors: Glazkova, P.A., Kulikov, D.A., Glazkov, A.A., Terpigorev, S.A., Rogatkin, D.A., Shekhyan, G.G., Krasulina, K.A., Kulikov, A.V., Makmatov-Rys, M.B., Paleev, F.N.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2021
• Subjects: risk factors; skin; laser-Doppler flowmetry; diabetes mellitus; Cardiovascular diseases; microcirculation; hypertension
• ISSN: 1386-0291; 1875-8622
• DOI: 10.3233/CH-201016

BACKGROUND: The role of microcirculatory disorders is progressively being accepted in the pathogenesis of cardiovascular diseases. OBJECTIVE: The purpose of current study is to assess whether we can consider skin microcirculation disorders as a biomarker of cardiovascular events. METHODS: Group 1 consisted of healthy volunteers (n = 31); group 2 (n = 42) consisted of patients with diseases that increase the risk of cardiovascular events; group 3 (n = 39) included patients with the history of cardiovascular events. Skin microcirculation measurement was performed using laser Doppler flowmetry during the heating test. RESULTS: LDF parameters reflecting the rapid response of microcirculation to heating (“Slope 120 s” and “Slope 180 s”) significantly differed in three groups (p <  0.05). A decrease in the “Slope 180 s” parameter less than 0.5 PU/s is associated with cardiovascular events (sensitivity 69.2%, specificity 66.7%; the area under the ROC curve, 0.667; 95% confidence interval [CI], 0.545–0.788, p = 0.01). Multivariable logistic regression analysis revealed that “Slope 180 s≤0.5 PU/s” was significantly related to cardiovascular events (adjusted odds ratio = 3.9, p = 0.019, CI 95% 1.2–12). CONCLUSIONS: Reduced reactivity of the skin microcirculation may be useful as a biomarker of severe damage to the cardiovascular system and is promising as a risk factor for cardiovascular events.