Development of novel efficient 2D nanocomposite catalyst towards the three-component coupling reaction for the synthesis of imidazo[1,2-a]pyridines

• Published in: Applied catalysis. A, General Vol. 542; pp. 368 - 379
• Main Authors: Hussain, Najrul, Gogoi, Pranjal, Das, Manash R., Sengupta, Pinaki, Fedorov, Vladimir E., Asanov, Igor P., Kozlova, Mariia N., Artemkina, Sofya B.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Science SA 25.07.2017
• Subjects: Alkynes; Boron nitride; Catalysis; Catalysts; Catalytic activity; Chemical synthesis; Copper; Copper oxides; Copper sulfides; Functional groups; Heterocyclic compounds; Nanocomposites; Pyridines; Studies
• ISSN: 0926-860X; 1873-3875
• DOI: 10.1016/j.apcata.2017.05.033

Two dimensional (2D) materials such as graphene and functionalized hexagonal boron nitride (h-BN) supported copper catalysts (CuO/rGO, CuO/h-BN, Cu(0)/rGO, Cu(0)/h-BN, CuS/rGO and CuS/h-BN) were prepared, characterized and evaluated their catalytic activity for the synthesis of imidazo[1,2-a]pyridines via one pot three component reaction between 2-aminopyridine, aldehyde and terminal alkynes. The imidazo[1,2-a]pyridines are an imperative class of nitrogen ring containing heterocyclic compounds which has wide range of applications in medicinal chemistry and drug molecule production. The reported synthetic protocol provides a rapid access to substituted imidazo[1,2-a]pyridines with excellent yields. CuO/rGO nanocomposite material was found to be highly active catalyst for the aforementioned reaction. The advantages of our protocol for the preparation of imidazo[1,2-a]pyridines over other previously reported includes shorter reaction times, functional group tolerance, recyclable catalyst and additive-free.