N-substituted dibutoxyphosphorylacetimidates in phosphorylation reactions

Reaction of N -substituted dibutoxyphosphorylacetimidates with sodium followed by phosphorylation of sodium derivatives with dialkyl chlorophosphates and phenyl dichlorophosphate proceeds selectively under mild conditions to form products of phosphorylation of the methylene group. The synthesized co...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 87; no. 9; pp. 2133 - 2136
Main Authors Shishkin, V. E., Popov, Yu. V., Anishchenko, O. V., Shevchenko, M. A., Ledenev, S. M., Moroz, A. A., Kosheleva, I. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.09.2017
Springer Nature
Springer Nature B.V
Subjects
Biological activity
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Letters to the Editor
Phosphorylation
Physical Sciences
Science & Technology
CH acids
phosphorylated acetimidates
phosphorylation
biologically active compounds
C-phosphorylated acetimidates
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Summary:Reaction of N -substituted dibutoxyphosphorylacetimidates with sodium followed by phosphorylation of sodium derivatives with dialkyl chlorophosphates and phenyl dichlorophosphate proceeds selectively under mild conditions to form products of phosphorylation of the methylene group. The synthesized compounds possess potential antisecretory, immunosuppressive, hypolipidemic, and other types of biological activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363217090390