Synthesis of polyoxymethylene derivatives of 1-oxytriaz-1-ene 2-oxides as the novel promising donors of nitric oxide in the living organisms

Novel both symmetric and asymmetric polyoxymethylene derivatives of bis(oxytriazene N -oxides) were synthesized by the nucleophilic substitution of bis(chloromethyl) ether with salts of oxytriazene N-oxides, their pharmacological properties were preliminary evaluated.

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Bibliographic Details
Published inRussian chemical bulletin Vol. 69; no. 10; pp. 1994 - 1998
Main Authors Nikitin, S. V., Luk’yanov, O. A.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.10.2020
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
Full Articles
Inorganic Chemistry
Nitric oxide
Organic Chemistry
oxytriazene
polyethers
oxides
ambident anions
NO donors
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Summary:Novel both symmetric and asymmetric polyoxymethylene derivatives of bis(oxytriazene N -oxides) were synthesized by the nucleophilic substitution of bis(chloromethyl) ether with salts of oxytriazene N-oxides, their pharmacological properties were preliminary evaluated.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-020-2990-5