Prolonged secretion of IL-15 in patients with severe forms of acute graft-versus-host disease after allogeneic bone marrow transplantation in children

Graft-versus-host disease (GVHD) is one of the most common and fatal complications that follows allogeneic bone marrow transplantation (BMT). Donor origin T cells are responsible for the initiation of GVHD. In this report, we demonstrate that conditioning regimens for BMT resulted in elevated serum...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of hematology Vol. 67; no. 3; p. 307
Main Authors Kumaki, S, Minegishi, M, Fujie, H, Sasahara, Y, Ohashi, Y, Tsuchiya, S, Konno, T
Format Journal Article
LanguageEnglish
Published Japan 01.04.1998
Subjects
Acute Disease
Adolescent
Bone Marrow Transplantation
Child
Child, Preschool
Female
Graft vs Host Disease - immunology
Humans
Infant
Interleukin-15 - immunology
Interleukin-15 - secretion
Male
Time Factors
Transplantation, Homologous
Online AccessGet more information

Cover

More Information
Summary:Graft-versus-host disease (GVHD) is one of the most common and fatal complications that follows allogeneic bone marrow transplantation (BMT). Donor origin T cells are responsible for the initiation of GVHD. In this report, we demonstrate that conditioning regimens for BMT resulted in elevated serum levels of interleukin-15 (IL-15), which reached maximum levels within 15 days and returned to basal levels within 25 days after allogeneic BMT, in all patients examined. Thereafter, circulating IL-15 was detected only in patients with grade III or IV acute GVHD with gut involvement. In contrast, IL-2 was not detected at any time in these patients. Since IL-15 is able to activate antigen-stimulated T cells and natural killer (NK) cells, IL-15 may play an important role in the development of severe forms of acute GVHD.
ISSN:0925-5710
DOI:10.1016/s0925-5710(97)00117-5