Cytotoxic and Antitumor Activity of Liposomal Silibinin

The cytotoxic and antitumor effect of liposomal form of silibinin was studied. It was shown that the liposomal silibinin reveals more pronounced cytotoxic activity in vitro against HeLa (cervix carcinoma), HT1080 (fibrosarcoma), and MCF-7 (breast adenocarcinoma) human tumor cell lines compared with...

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Bibliographic Details
Published inBioNanoScience Vol. 8; no. 4; pp. 971 - 976
Main Authors Feldman, Nataliya B., Gromovykh, Tatiana I., Sedyakina, Natalia E., Krasnyuk, Ivan I., Lutsenko, Sergey V.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.12.2018
Springer Nature B.V
Subjects
Adenocarcinoma
Animals
Anticancer properties
Antitumor activity
Biological and Medical Physics
Biomaterials
Biophysics
Cervical carcinoma
Cervix
Circuits and Systems
Cytotoxicity
Engineering
Fibrosarcoma
Intravenous administration
Lecithin
Life span
Nanotechnology
Silibinin
Tumor cell lines
Tumors
Drug delivery systems
Antitumor agents
Liposomes
Murine mammary adenocarcinoma
Silibinin
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Summary:The cytotoxic and antitumor effect of liposomal form of silibinin was studied. It was shown that the liposomal silibinin reveals more pronounced cytotoxic activity in vitro against HeLa (cervix carcinoma), HT1080 (fibrosarcoma), and MCF-7 (breast adenocarcinoma) human tumor cell lines compared with non-liposomal silibinin. In vivo experiments demonstrated a possibility of parenteral use of the liposomal form. It was demonstrated that intravenous administration of liposomal silibinin has a significant antitumor effect in vivo against murine adenocarcinoma of Ca 755 and leads to inhibition of tumor growth (53.6%) and an increase (49.4%) in the mean life span of experimental animals compared to untreated control and animals receiving non-liposomal forms (free silibinin and its mixture with lecithin) administered orally.
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-018-0556-x