Influence of the external noise intensity on the kinetics of ligands binding to receptors

The average, variance, correlation function and the spectral density of ligand–receptor complexes in the presence of the external Langevin noise are calculated and their characteristics are defined. The analysis of the experimental data using the formulas derived in this work enables one to obtain a...

Full description

Saved in:
Bibliographic Details
Published inJournal of contemporary physics Vol. 52; no. 1; pp. 70 - 75
Main Authors Arakelyan, V. B., Danko, V. P., Grigoryan, R. P.
Format Journal Article
LanguageEnglish
Published New York Allerton Press 2017
Springer Nature B.V
Subjects
Online AccessGet full text

Cover

Loading…
Abstract The average, variance, correlation function and the spectral density of ligand–receptor complexes in the presence of the external Langevin noise are calculated and their characteristics are defined. The analysis of the experimental data using the formulas derived in this work enables one to obtain a new information on the process of forming of ligand–receptor complex, namely, the constants rates of formation and the decay of the ligand–receptor complex.
AbstractList The average, variance, correlation function and the spectral density of ligand–receptor complexes in the presence of the external Langevin noise are calculated and their characteristics are defined. The analysis of the experimental data using the formulas derived in this work enables one to obtain a new information on the process of forming of ligand–receptor complex, namely, the constants rates of formation and the decay of the ligand–receptor complex.
Author Danko, V. P.
Arakelyan, V. B.
Grigoryan, R. P.
Author_xml – sequence: 1
  givenname: V. B.
  surname: Arakelyan
  fullname: Arakelyan, V. B.
  email: v.arakelyan@ysu.am
  organization: Yerevan State University
– sequence: 2
  givenname: V. P.
  surname: Danko
  fullname: Danko, V. P.
  organization: Krasnodar Branch of the Plekhanov Russian University of Economics
– sequence: 3
  givenname: R. P.
  surname: Grigoryan
  fullname: Grigoryan, R. P.
  organization: Yerevan State University
BookMark eNp1kE1LxDAQhoMouLv6A7wFPFczTZukR1n8WFjwoIKeSppO16w1WZMsuP_e1vUgiKcZeJ53YN4pOXTeISFnwC44MH75AEwozmUOkgEDeD4gE6h4kVVcqsNhH3A28mMyjXHNWFkOdEJeFq7rt-gMUt_R9IoUPxMGp3vqvI1IrUvook076t03f7MOkzVx9Hu70q6NtLGutW5Fk6cBDW6SD_GEHHW6j3j6M2fk6eb6cX6XLe9vF_OrZWY4iJSBFhXrSq1yA8Io1uSGtVKWZZGzChqlsdVFJ5pCcaMQWi5F22kFzJSVrhD5jJzv726C_9hiTPXab8cHYg1KMVnmAsRgwd4ywccYsKs3wb7rsKuB1WOD9Z8Gh0y-z8TBdSsMvy7_G_oCsGl01Q
CitedBy_id crossref_primary_10_1134_S0021894418040132
Cites_doi 10.1073/pnas.0804702105
10.1016/0375-9601(78)90194-9
10.1143/PTP.64.1233
10.1155/2014/143023
10.1016/S0006-3495(77)85544-6
10.1080/07391102.2002.10506829
ContentType Journal Article
Copyright Allerton Press, Inc. 2017
Copyright Springer Science & Business Media 2017
Copyright_xml – notice: Allerton Press, Inc. 2017
– notice: Copyright Springer Science & Business Media 2017
DBID AAYXX
CITATION
DOI 10.3103/S106833721701011X
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList

DeliveryMethod fulltext_linktorsrc
Discipline Physics
EISSN 1934-9378
EndPage 75
ExternalDocumentID 10_3103_S106833721701011X
GroupedDBID -5F
-5G
-BR
-EM
-Y2
-~C
.86
.VR
06D
0R~
0VY
1N0
29K
29~
2J2
2JN
2JY
2KG
2KM
2LR
2VQ
2~H
30V
4.4
408
40D
40E
5GY
5VS
6NX
8TC
95-
95.
95~
96X
AAAVM
AABHQ
AAFGU
AAHNG
AAIAL
AAJKR
AANZL
AARHV
AARTL
AATNV
AATVU
AAUYE
AAWCG
AAYFA
AAYIU
AAYQN
AAYTO
ABDZT
ABECU
ABFGW
ABFTV
ABHQN
ABJNI
ABJOX
ABKAS
ABKCH
ABMNI
ABMQK
ABNWP
ABQBU
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABWNU
ABXPI
ACBMV
ACBRV
ACBXY
ACBYP
ACCUX
ACGFS
ACHSB
ACHXU
ACIGE
ACIPQ
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACSNA
ACTTH
ACVWB
ACWMK
ADHHG
ADINQ
ADKNI
ADMDM
ADOXG
ADRFC
ADURQ
ADYFF
ADZKW
AEBTG
AEFTE
AEGAL
AEGNC
AEJHL
AEJRE
AEOHA
AEPYU
AESTI
AETLH
AEVLU
AEVTX
AEXYK
AFGCZ
AFLOW
AFNRJ
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGGBP
AGJBK
AGMZJ
AGQMX
AGWIL
AGWZB
AGYKE
AHAVH
AHBYD
AHKAY
AHSBF
AIAKS
AIIXL
AILAN
AIMYW
AITGF
AJBLW
AJDOV
AJRNO
AKQUC
ALMA_UNASSIGNED_HOLDINGS
ALWAN
AMKLP
AMXSW
AMYLF
AMYQR
AOCGG
ARMRJ
AXYYD
B-.
BA0
BDATZ
BGNMA
CAG
COF
CS3
D-I
DDRTE
DNIVK
DPUIP
EBLON
EBS
EIOEI
EJD
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FSGXE
FWDCC
GGCAI
GGRSB
GJIRD
GNWQR
GQ6
GQ7
HF~
HG6
HLICF
HMJXF
HRMNR
HZ~
IJ-
IKXTQ
IWAJR
I~X
I~Z
J-C
JBSCW
JZLTJ
KOV
LLZTM
M4Y
MA-
NPVJJ
NQJWS
NU0
O9-
O93
O9J
P9T
PF0
PT4
QOS
R89
R9I
RNS
ROL
RPX
RSV
S16
S1Z
S27
S3B
SAP
SDH
SHX
SNE
SNPRN
SNX
SOHCF
SOJ
SPH
SPISZ
SRMVM
SSLCW
STPWE
SZN
T13
TSG
TUC
U2A
UG4
UNUBA
UOJIU
UTJUX
UZXMN
VC2
VFIZW
WK8
XU3
YLTOR
ZMTXR
~A9
AACDK
AAJBT
AASML
AAYXX
ABAKF
ACAOD
ACDTI
ACZOJ
AEFQL
AEMSY
AGRTI
AIGIU
CITATION
H13
SJYHP
ID FETCH-LOGICAL-c316t-1a690f5a82c16c80b2c0d775542091b8aeda4f6b483c8e1d376dfa810c59a9ee3
IEDL.DBID U2A
ISSN 1068-3372
IngestDate Thu Oct 10 20:03:03 EDT 2024
Thu Sep 12 16:54:27 EDT 2024
Sat Dec 16 12:00:54 EST 2023
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords external noise
variance
ligand–receptor complex
correlation function
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c316t-1a690f5a82c16c80b2c0d775542091b8aeda4f6b483c8e1d376dfa810c59a9ee3
PQID 1880752616
PQPubID 2044298
PageCount 6
ParticipantIDs proquest_journals_1880752616
crossref_primary_10_3103_S106833721701011X
springer_journals_10_3103_S106833721701011X
PublicationCentury 2000
PublicationDate 1-2017
2017-1-00
20170101
PublicationDateYYYYMMDD 2017-01-01
PublicationDate_xml – year: 2017
  text: 1-2017
PublicationDecade 2010
PublicationPlace New York
PublicationPlace_xml – name: New York
PublicationTitle Journal of contemporary physics
PublicationTitleAbbrev J. Contemp. Phys
PublicationYear 2017
Publisher Allerton Press
Springer Nature B.V
Publisher_xml – name: Allerton Press
– name: Springer Nature B.V
References De la RubiaJ.VelardeM.G.Phys. Lett. A1978693041978PhLA...69..304D58758810.1016/0375-9601(78)90194-9
Cell Signaling Reactions: Single-Molecular Kinetic Analysis, Y. Sako, M. Ueda, Eds., Springer Science+ Business Media, 2011.
KitaharaK.HorsthemkeW.LefeverR.InabaYu.Prog. Theor. Phys.19806412331980PThPh..64.1233K10.1143/PTP.64.1233
RappelW.-J.LevineH.PNAS2008105192702008PNAS..10519270R10.1073/pnas.0804702105
HorsthemkeW.LefeverR.Noise-Induced Transitions1984Berlin, Heidelberg, New York, TokyoSpringer-Verlag0529.60085
BergH.C.PurcellE.M.Biophys. J.1977201931977BpJ....20..193B10.1016/S0006-3495(77)85544-6
ArakelyanV.B.HaroutiunianS.G.ArakelyanH.V.HaroutunyanT.S.J. Biomol. Struct. Dyn.20022012510.1080/07391102.2002.10506829
HumphreyP.P.A.BarnardE.A.Pharmacol. Reviews199850271
ChattopadhyayA.Advances in Biology201420141210.1155/2014/143023
VarfolomeevS.D.GurevichK.G.Biokinetika1999
P.P.A. Humphrey (6444_CR2) 1998; 50
K. Kitahara (6444_CR7) 1980; 64
J. Rubia De la (6444_CR6) 1978; 69
H.C. Berg (6444_CR3) 1977; 20
W. Horsthemke (6444_CR9) 1984
S.D. Varfolomeev (6444_CR4) 1999
W.-J. Rappel (6444_CR8) 2008; 105
V.B. Arakelyan (6444_CR10) 2002; 20
A. Chattopadhyay (6444_CR1) 2014; 2014
6444_CR5
References_xml – volume-title: Noise-Induced Transitions
  year: 1984
  ident: 6444_CR9
  contributor:
    fullname: W. Horsthemke
– volume-title: Biokinetika
  year: 1999
  ident: 6444_CR4
  contributor:
    fullname: S.D. Varfolomeev
– volume: 105
  start-page: 19270
  year: 2008
  ident: 6444_CR8
  publication-title: PNAS
  doi: 10.1073/pnas.0804702105
  contributor:
    fullname: W.-J. Rappel
– volume: 69
  start-page: 304
  year: 1978
  ident: 6444_CR6
  publication-title: Phys. Lett. A
  doi: 10.1016/0375-9601(78)90194-9
  contributor:
    fullname: J. Rubia De la
– volume: 64
  start-page: 1233
  year: 1980
  ident: 6444_CR7
  publication-title: Prog. Theor. Phys.
  doi: 10.1143/PTP.64.1233
  contributor:
    fullname: K. Kitahara
– volume: 2014
  start-page: 12
  year: 2014
  ident: 6444_CR1
  publication-title: Advances in Biology
  doi: 10.1155/2014/143023
  contributor:
    fullname: A. Chattopadhyay
– volume: 20
  start-page: 193
  year: 1977
  ident: 6444_CR3
  publication-title: Biophys. J.
  doi: 10.1016/S0006-3495(77)85544-6
  contributor:
    fullname: H.C. Berg
– volume: 50
  start-page: 271
  year: 1998
  ident: 6444_CR2
  publication-title: Pharmacol. Reviews
  contributor:
    fullname: P.P.A. Humphrey
– ident: 6444_CR5
– volume: 20
  start-page: 125
  year: 2002
  ident: 6444_CR10
  publication-title: J. Biomol. Struct. Dyn.
  doi: 10.1080/07391102.2002.10506829
  contributor:
    fullname: V.B. Arakelyan
SSID ssj0055934
Score 2.0578277
Snippet The average, variance, correlation function and the spectral density of ligand–receptor complexes in the presence of the external Langevin noise are calculated...
SourceID proquest
crossref
springer
SourceType Aggregation Database
Publisher
StartPage 70
SubjectTerms Coordination compounds
Ligands
Noise intensity
Particle and Nuclear Physics
Physics
Physics and Astronomy
Receptors
Title Influence of the external noise intensity on the kinetics of ligands binding to receptors
URI https://link.springer.com/article/10.3103/S106833721701011X
https://www.proquest.com/docview/1880752616
Volume 52
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV09T8MwED2VVkgsiE9RKMgDEyiQOE7sjhVqKSBYoFI7RY5jo6ooqWgY-PecnYZvBmafPJyTu_d853cAx0phjhKUeyYKhMfw0D3JTealJg056zJJ3fSG27t4OGLX42jcAPp-dZHPzuqKpAvUjlb64fk9chcRhkhYuJVFC8Yr0ELswGwb14j26uiLALmqJKO1Z82rSubvW3zNRR8A81tN1KWawQasLzEi6VWHugkNnW_BquvVVIttmFzVg0VIYQgCOFJLOZO8mC40mVZt6eUrKXK3PkMoaeWYrf3T9NG-7iXp1L1nIWVBMOjpuZ26swOjQf_hYugtJyR4Kgzi0gskklsTSUFVECvhp1T5Gefofoo4IBVSZ5KZOGUiVEIHGUaTzEgR-Crqyq7W4S408yLXe0DiONMqMJwpzZnIrCw91cowFkmKgSBrw0ntq2ReCWEkSCCsY5Mfjm1Dp_ZmsvwnFolVfuMRMra4Dae1hz8t_7XZ_r-sD2CN2szrbkk60CyfX_Qh4oYyPYJW73Jy0z9yH8wboBi5eg
link.rule.ids 315,783,787,27938,27939,41095,41537,42164,42606,52125,52248
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV09T8MwELWgCMGC-BSFAh6YQBaN48TuWCGqFtoutFKZIsexUQRKKhIG_j1nJxHfA7NPHp6du3e58zuEzpWCGCUoJybwBGFw6ERyk5DYxD5nPSapm94wmYbDObtdBIv6HXfRdLs3JUnnqV1e2fWv7iF5Eb4PGQu3umjeYhWtWXl1e63ntN-4X2DIVSkZrIk1r0qZv2_xNRh9MMxvRVEXawbbaKsmibhfneoOWtHZLlp3zZqq2EMPo2ayCM4NBgaHGy1nnOVpoXFa9aWXbzjP3PoTcEmrx2ztn9NH-7wXx6l70ILLHIPX00s7dmcfzQc3s-shqUckEOV7YUk8CdmtCaSgyguV6MZUdRPOAX8KRCAWUieSmTBmwldCewm4k8RI4XVV0JM9rf0D1MryTB8iHIaJVp7hTGnORGJ16alWhrFAUvAESRtdNFhFy0oJI4IMwgIb_QC2jToNmlH9URSRlX7jAaRsYRtdNgh_Wv5rs6N_WZ-hjeFsMo7Go-ndMdqkNgy7XyYd1CpfXvUJkIgyPnWX5h29WbtB
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT8MwDLZgCMSFN2I8c-AEKlvbtMmOCBhvhARI41TSPNAEaidWDvDrcdpGvA-Ic9K0tVP7c-18BtiUEn0UD5hnIp97FJXuCWaUl5o0ZLRDRVB2bzi_iI9u6Ekv6tV9Toeu2t2lJKszDZalKStaA2VaZYzZDltXGMjwMMTohVmONL83CmN4n07UgLHdw9vTA2eMES9XiWWc79kLqsTmz4t8dk3vePNLirT0PN1puHPPXBWcPOw8F-mOfP1C5_iPl5qBqRqVkt1qG83CiM7mYLysDpXDebg9dq1MSG4IQkbiyKNJlveHmvSrQvjiheRZOf6A4NUSQNv5j_17e56YpP3yBA0pcoJmVg9sn58FuOkeXO8deXVPBk-Gflx4vsBw2kSCB9KPJW-ngWwrxlDhASKPlAutBDVxSnkoufYV2i9lBPfbMuqIjtbhIjSyPNNLQOJYaekbRqVmlCtLhB9oaSiNRICmRzVhy6kjGVTUGwmGLFZWyTdZNWHVKSypv8JhYrnmWIQxYtyEbSf_D8O_Lbb8p9kbMHG5303Oji9OV2AysG6__EWzCo3i6VmvIWgp0vV6Y74BN6Lg9Q
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Influence+of+the+external+noise+intensity+on+the+kinetics+of+ligands+binding+to+receptors&rft.jtitle=Journal+of+contemporary+physics&rft.au=Arakelyan%2C+V.+B.&rft.au=Danko%2C+V.+P.&rft.au=Grigoryan%2C+R.+P.&rft.date=2017-01-01&rft.pub=Allerton+Press&rft.issn=1068-3372&rft.eissn=1934-9378&rft.volume=52&rft.issue=1&rft.spage=70&rft.epage=75&rft_id=info:doi/10.3103%2FS106833721701011X&rft.externalDocID=10_3103_S106833721701011X
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1068-3372&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1068-3372&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1068-3372&client=summon