Influence of the external noise intensity on the kinetics of ligands binding to receptors
The average, variance, correlation function and the spectral density of ligand–receptor complexes in the presence of the external Langevin noise are calculated and their characteristics are defined. The analysis of the experimental data using the formulas derived in this work enables one to obtain a...
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Published in | Journal of contemporary physics Vol. 52; no. 1; pp. 70 - 75 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
New York
Allerton Press
2017
Springer Nature B.V |
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Abstract | The average, variance, correlation function and the spectral density of ligand–receptor complexes in the presence of the external Langevin noise are calculated and their characteristics are defined. The analysis of the experimental data using the formulas derived in this work enables one to obtain a new information on the process of forming of ligand–receptor complex, namely, the constants rates of formation and the decay of the ligand–receptor complex. |
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AbstractList | The average, variance, correlation function and the spectral density of ligand–receptor complexes in the presence of the external Langevin noise are calculated and their characteristics are defined. The analysis of the experimental data using the formulas derived in this work enables one to obtain a new information on the process of forming of ligand–receptor complex, namely, the constants rates of formation and the decay of the ligand–receptor complex. |
Author | Danko, V. P. Arakelyan, V. B. Grigoryan, R. P. |
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Keywords | external noise variance ligand–receptor complex correlation function |
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References | De la RubiaJ.VelardeM.G.Phys. Lett. A1978693041978PhLA...69..304D58758810.1016/0375-9601(78)90194-9 Cell Signaling Reactions: Single-Molecular Kinetic Analysis, Y. Sako, M. Ueda, Eds., Springer Science+ Business Media, 2011. KitaharaK.HorsthemkeW.LefeverR.InabaYu.Prog. Theor. Phys.19806412331980PThPh..64.1233K10.1143/PTP.64.1233 RappelW.-J.LevineH.PNAS2008105192702008PNAS..10519270R10.1073/pnas.0804702105 HorsthemkeW.LefeverR.Noise-Induced Transitions1984Berlin, Heidelberg, New York, TokyoSpringer-Verlag0529.60085 BergH.C.PurcellE.M.Biophys. J.1977201931977BpJ....20..193B10.1016/S0006-3495(77)85544-6 ArakelyanV.B.HaroutiunianS.G.ArakelyanH.V.HaroutunyanT.S.J. Biomol. Struct. Dyn.20022012510.1080/07391102.2002.10506829 HumphreyP.P.A.BarnardE.A.Pharmacol. Reviews199850271 ChattopadhyayA.Advances in Biology201420141210.1155/2014/143023 VarfolomeevS.D.GurevichK.G.Biokinetika1999 P.P.A. Humphrey (6444_CR2) 1998; 50 K. Kitahara (6444_CR7) 1980; 64 J. Rubia De la (6444_CR6) 1978; 69 H.C. Berg (6444_CR3) 1977; 20 W. Horsthemke (6444_CR9) 1984 S.D. Varfolomeev (6444_CR4) 1999 W.-J. Rappel (6444_CR8) 2008; 105 V.B. Arakelyan (6444_CR10) 2002; 20 A. Chattopadhyay (6444_CR1) 2014; 2014 6444_CR5 |
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SubjectTerms | Coordination compounds Ligands Noise intensity Particle and Nuclear Physics Physics Physics and Astronomy Receptors |
Title | Influence of the external noise intensity on the kinetics of ligands binding to receptors |
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