Caffeine stimulates in vivo platelet reactivity

The effect of coffee drinking on platelet reactivity was studied in 12 healthy subjects. Plasma beta-thromboglobulin concentration was determined before and one hour after administration of 100 mg of caffeine, corresponding to one cup of coffee. Mean values were 47.0 +/- 19.3 and 179.3 +/- 85.5 ng/m...

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Bibliographic Details
Published inActa medica Scandinavica Vol. 224; no. 3; p. 245
Main Authors Ammaturo, V, Perricone, C, Canazio, A, Ripaldi, M, Ruggiano, A, Zuccarelli, B, Monti, M
Format Journal Article
LanguageEnglish
Published Sweden 01.01.1988
Subjects
Adult
beta-Thromboglobulin - blood
Blood Platelets - drug effects
Caffeine - pharmacology
Coffee
Female
Humans
Male
Middle Aged
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Summary:The effect of coffee drinking on platelet reactivity was studied in 12 healthy subjects. Plasma beta-thromboglobulin concentration was determined before and one hour after administration of 100 mg of caffeine, corresponding to one cup of coffee. Mean values were 47.0 +/- 19.3 and 179.3 +/- 85.5 ng/ml before and after caffeine administration respectively. The increase, 298 +/- 150%, is highly significant (p less than 0.001).
ISSN:0001-6101
DOI:10.1111/j.0954-6820.1988.tb19368.x