Analysis of HLA‐DRB1 alleles in Japanese patients with chronic myelogenous leukemia

• Published in: American journal of hematology Vol. 63; no. 2; pp. 99 - 101
• Main Authors: Yasukawa, Masaki, Ohminami, Hideki, Kojima, Kensuke, Inokuchi, Koiti, Nishimura, Yasuharu, Fujita, Shigeru
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.02.2000; Wiley-Liss
• Subjects: Alleles; bcr‐abl fusion protein; Biological and medical sciences; CD4+ T lymphocytes; chronic myelogenous leukemia; Fusion Proteins, bcr-abl - genetics; Gene Frequency - genetics; genetic association; Genotype; Hematologic and hematopoietic diseases; HLA-DR Antigens - genetics; HLA-DRB1 Chains; HLA‐DRB1; Humans; Japan; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Polymorphism, Restriction Fragment Length; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Japan; Chromosomal aberration; Human; Pathogenesis; HLA-DR-System; Major histocompatibility system; Class II histocompatibility antigen; Helper cell; Genotype; Malignant hemopathy; Cellular immunity; Genetic determinism; Cell subpopulation; Myeloproliferative syndrome; Chronic; C-Onc gene; Chronic myelocytic leukemia; T-Lymphocyte; Abnormal chromosome; Hybrid gene; Protooncogene; Chromosome translocation
• ISSN: 0361-8609; 1096-8652
• DOI: 10.1002/(SICI)1096-8652(200002)63:2<99::AID-AJH8>3.0.CO;2-#

To clarify the association between HLA‐DRB1 alleles and chronic myelogenous leukemia (CML), the HLA‐DRB1 allele frequencies in 50 Japanese patients each with b2a2 and b3a2 CML and 127 healthy Japanese individuals were examined. In the patients with b2a2 CML, the frequencies of HLA‐DRB1*0405, DRB1*08032, and DRB1*1502 were low and that of HLA‐DRB1*1201 was high in comparison with the healthy individuals. The frequencies of HLA‐DRB1*0403, DRB1*0802, DRB1*1403, and DRB1*1405 were high, and those of HLA‐DRB1*08032 and DRB1*1501 were low in the patients with b3a2 CML. The present results suggest positive and negative associations between certain HLA‐DRB1 alleles and CML. Am. J. Hematol. 63:99–101, 2000. © 2000 Wiley‐Liss, Inc.