Metastatic pulmonary calcifications after pediatric liver transplantation

• Published in: Pediatric transplantation Vol. 28; no. 1; pp. e14693 - n/a
• Main Authors: Chiu, Megan Z., Cuenca, Alex G., Koo, Donna C., Hartjes, Kayla, Wehrman, Andrew, Kim, Heung Bae, Lee, Eliza J.
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.02.2024
• Subjects: Biopsy; Calcification; case series; Children; Diagnosis; Literature reviews; Liver transplantation; Liver transplants; Lungs; Metastases; Patients; Pediatrics; pulmonary calcifications; Renal failure; case series; liver transplantation; pediatrics; pulmonary calcifications
• ISSN: 1397-3142; 1399-3046
• DOI: 10.1111/petr.14693

Background Pulmonary calcification (PC) is a rare clinical entity observed following liver transplantation (LT). Most often identified in adults or in patients with concomitant renal failure, PC is rarely reported in children. While the clinical course of PC is largely benign, cases of progressive respiratory failure and death have been reported. Additionally, PC may mimic several other disease processes making diagnosis and management challenging. Currently, little is reported regarding the diagnosis, management, and long‐term outcomes of children with PC following LT. Methods We performed a retrospective chart review of patients undergoing LT at our institution between 2006 and 2023. We identified two patients who developed PC following LT. Their diagnosis, clinical course, and long‐term outcomes are reported. A literature review of the presentation, diagnosis, management, and outcomes of adult and pediatric patients with PC post‐LT was also performed. Conclusions Pulmonary calcifications are a rare but notable complication after pediatric liver transplantation. Our case series adds to the limited literature on this clinical entity in children but also highlights the fact that effective diagnosis and treatment may be safely accomplished without the use of lung biopsy.