Temporal profiles of neuronal responses to repeated tone stimuli in the mouse primary auditory cortex

• Published in: Hearing research Vol. 430; p. 108710
• Main Authors: Zhou, Bo, Tomioka, Ryohei, Song, Wen-Jie
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2023
• Subjects: Acoustic Stimulation - methods; Animals; Auditory cortex; Auditory Cortex - physiology; Electrophysiology; Mice; Monotonic; Neurons - physiology; Non-monotonic; Single-unit activity; Sound; Single-unit activity; Monotonic; Auditory cortex; Non-monotonic
• ISSN: 0378-5955; 1878-5891
• DOI: 10.1016/j.heares.2023.108710

•A variety of response temporal profiles of A1 neurons to a tone-train was revealed.•Profiles of the “facilitation” and “adaptation” categories changed monotonically.•Non-monotonic profiles were mainly of the “adaptation with recovery” category.•Profile category was either frequency-dependent or -independent in single neurons. How the auditory system processes temporal information of sound has been investigated extensively using repeated stimuli. Recent studies on how the response of neurons in the primary auditory cortex (A1) changes with the progression of stimulus repetition, have reported response temporal profiles of two categories: “adaptation”, i.e., gradual decrease, and “facilitation”, i.e., gradual increase. To explore the existence of profiles of other categories and to examine the tone-frequency-dependence of the profile category in single neurons, here we studied the response of mouse A1 neurons to four or five tone-trains; each train comprised 10 identical tone pips, with 0.5-s inter-tone-intervals, and the four or five trains differed only in tone frequency. The response to each tone in a train was evaluated using the peak of the ON response, and how the peak response changed with the tone number in the train, i.e., the response temporal profile, was examined. We confirmed the existence of profiles of both “adaptation” and “facilitation” categories; “adaptation” could be further subcategorized into “slow adaptation” and “fast adaptation” profiles, with the latter being encountered more frequently. Moreover, two new categories of non-monotonic profiles were identified: an “adaptation with recovery” profile and a “facilitation followed by adaptation” profile. Examination of single neurons with trains of different tone frequencies revealed that some A1 neurons exhibited profiles of the same category to tone trains of different tone frequencies, whereas others exhibited profiles of different categories, depending on the tone frequency. These results demonstrate the variety in the response temporal profiles of mouse A1 neurons, which may benefit the encoding of individual tones in a train.