The Dopaminergic System of the Telencephalo-Diencephalic Areas of the Vertebrate Brain in the Organization of the Sleep–Waking Cycle

• Published in: Neuroscience and behavioral physiology Vol. 39; no. 8; pp. 805 - 817
• Main Authors: Oganesyan, G. A., Romanova, I. V., Aristakesyan, E. A., Kuzik, V. V., Makina, D. M., Morina, I. Yu, Khramenkova, A. É., Artamokhina, I. V., Belova, V. A.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.10.2009; Springer Nature B.V
• Subjects: Acipenser; Animals; Behavioral Sciences; Biomedical and Life Sciences; Biomedicine; Diencephalon - enzymology; Diencephalon - growth & development; Diencephalon - metabolism; Dopamine - metabolism; Fishes; Immunohistochemistry; Neurobiology; Neurosciences; Rats; Sleep; Sleep Deprivation - enzymology; Stress, Psychological - enzymology; Telencephalon - enzymology; Telencephalon - growth & development; Telencephalon - metabolism; Touch; Tyrosine 3-Monooxygenase - metabolism; Wakefulness; brain; sleep–waking cycle; dopaminergic system
• ISSN: 0097-0549; 1573-899X
• DOI: 10.1007/s11055-009-9191-x

The aim of the present work was to study the involvement of the dopaminergic system of the telencephalic and diencephalic areas of the vertebrate brain in the organization of the sleep–waking cycle in cold-blooded and warm-blooded vertebrates. Immunohistochemical studies of tyrosine hydroxylase content, this being the key enzyme in dopamine synthesis, in the striatum, supraoptic and arcuate nuclei, and zona incerta of the hypothalamus of sturgeon and mammals (rats) of three age groups (14 and 30 days and adults), in conditions of tactile and sleep-deprivation stressors. In fish, transient stress was followed by the detection of tyrosine hydroxylase-immunoreactive cells in all parts of the brain. In prolonged stress, tyrosine hydroxylase-immunoreactive cells and fibers were not found in the forebrain, though they were well represented in the hypothalamic nuclei. In 14-day-old rat pups, 2-h sleep deprivation increased the tyrosine hydroxylase content of fibers in the caudate nucleus and cells in the zona incerta of the hypothalamus, while 30-day-old animals subjected to 6-h sleep deprivation showed increases in tyrosine hydroxylaseimmunoreactive material contents in cells in the paraventricular nucleus and decreases in the quantity in fibers. In adult rats, the arcuate nucleus and zona incerta showed decreases in the content of tyrosine hydroxylase-immunoreactive material on the background of sleep deprivation, with increases during postdeprivation sleep. These data are discussed in the light of the phylo- and ontogenetic development of the neurosecretory and neurotransmitter functions of the dopaminergic system in the evolutionarily ancient diencephalic and evolutionarily young telencephalic areas of the vertebrate brain as major systems triggering and maintaining the functional states of the body during the sleep–waking cycle.