Rhodium-catalyzed triazole-directed C-H bond functionalization of arenes with diazo compounds

Heterocyclic compounds bearing 1,2,3-triazole scaffolds have found wide application both in medicinal chemistry and materials science. In this paper, rhodium(iii)-catalyzed triazole-directed alkylation reactions of arenes using diazo compounds as the alkylating agents are described. A number of poly...

Full description

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 16; no. 43; pp. 8191 - 8195
Main Authors Wang, Huanhong, Yi, Xiaofei, Cui, Yanli, Chen, Wanzhi
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.11.2018
Royal Society of Chemistry
Subjects
Alkylating agents
Alkylation
Aromatic compounds
Catalysis
Chemical reactions
Chemistry
Chemistry, Organic
Crystallography
Data processing
Heterocyclic compounds
Hydrogen bonds
Materials science
Organic chemistry
Physical Sciences
Rhodium
Science & Technology
ACTIVATION
AZIDES
OLEFINATION
ANNULATION
1,2,3-TRIAZOLES
1,3-DIPOLAR CYCLOADDITION
REGIOSELECTIVE SYNTHESIS
NITROOLEFINS
ALKYNES
CYCLIZATION
Online AccessGet full text

Cover

More Information
Summary:Heterocyclic compounds bearing 1,2,3-triazole scaffolds have found wide application both in medicinal chemistry and materials science. In this paper, rhodium(iii)-catalyzed triazole-directed alkylation reactions of arenes using diazo compounds as the alkylating agents are described. A number of polysubstituted arenes were provided from easily available materials in good yields under mild conditions. The reactions proceed via triazole-directed ortho C-H bond activation and subsequent carbene insertion originating from diazo compounds.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob01673a