Hantavirus infections in the South‑Eastern European countries: A study of two cases and literature review

Hantavirus infection is a rare zoonosis in South-Eastern Europe. Depending on the serotype involved, the virus can cause hemorrhagic fever with renal syndrome which is also known as endemic nephropathy, and cardiopulmonary syndrome. Prompt diagnosis of the disease is essential for reducing the risk...

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Published inExperimental and therapeutic medicine Vol. 26; no. 3
Main Authors Lupusoru, Gabriela, Andronesi, Andreea Gabriella, Lupusoru, Mircea, Ailincai, Ioana, Sfeatcu, Ruxandra, Vacaroiu, Ileana, Banu, Mihaela, Achim, Camelia, Ismail, Gener
Format Journal Article
LanguageEnglish
Published Athens Spandidos Publications 01.09.2023
Spandidos Publications UK Ltd
D.A. Spandidos
Subjects
Anemia
Bar codes
Biopsy
Blood pressure
Case Report
Chronic kidney failure
Creatinine
Dehydrogenases
E coli
Enzymes
Epidemiology
Fever
Hantavirus
Health aspects
Hematuria
Hemorrhagic fever
Hypertension
Immunoglobulins
Infection
Infections
Instrument industry
Kidneys
Medical research
Medicine, Experimental
Microscopy
Pathogens
Polyuria
Salmonella
Serology
Thrombocytopenia
Urinalysis
Urine
Vaccines
Viral infections
Zoonoses
United States
Eastern Europe
Romania
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Summary:Hantavirus infection is a rare zoonosis in South-Eastern Europe. Depending on the serotype involved, the virus can cause hemorrhagic fever with renal syndrome which is also known as endemic nephropathy, and cardiopulmonary syndrome. Prompt diagnosis of the disease is essential for reducing the risk of severe manifestations and complications like chronic kidney disease, secondary hypertension or even death because there is no specific treatment or vaccine approved. The present study reported two cases of hemorrhagic fever with renal syndrome diagnosed in the Department of Nephrology of The Fundeni Clinical Institute (Romania). In both patients, kidney needle biopsy played a major role in establishing the diagnosis. The difficulties encountered in diagnosing this disease were also emphasized, taking into consideration the rarity of this infection in South-Eastern Europe. The key literature data on the epidemiology, pathogenesis and management of this infection were further reviewed.
Bibliography:Dr Mircea Lupușoru, Department of Physiology, The ‘Carol Davila’ University of Medicine and Pharmacy, Blvd Eroii Sanitari 8, 050474 Bucharest, Romania mircea.lupusoru@umfcd.ro
Contributed equally
Abbreviations: HFRS, hemorrhagic fever with renal syndrome; TMA, thrombotic microangiopathy; KB, kidney biopsy; ADAMTS 13, a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13; LDH, lactate dehydrogenase; C3, component 3 of the complement system; C4, component 4 of the complement system; ANCA, antineutrophil cytoplasmic antibody; anti-HIV, anti-human immunodeficiency virus antibody; AKI, acute kidney injury; HUS, hemolytic uremic syndrome; IF, immunofluorescence; LM, light microscopy; EM, electron microscopy; HTNV, Hantaan virus; PUUV, Puumala virus; DOBV, Dobrava virus; SEOV, Seoul virus; TULV, Tula virus; SAAV, Saaremaa virus
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2023.12129