Aza-[4+2] cycloadditions employing catalytically derived N-acyliminium ions

Herein, we report the development of a novel route to tricyclic lactam products via a facile aza-[4 + 2] cycloaddition of catalytically generated acyliminium ions. Employing a Ca(NTf2)(2)/nBu(4)NPF(6) catalyst system in low loadings, a range of diverse fused ring systems can be synthesised in predom...

Full description

Saved in:
Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 20; no. 42; pp. 8209 - 8211
Main Authors Owen, Niamh J., McLaughlin, Mark G.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 02.11.2022
Royal Society of Chemistry
Subjects
Amides
Catalysis
Catalysts
Chemistry
Chemistry, Organic
Cycloaddition
Cycloaddition Reaction
Ions
Physical Sciences
Science & Technology
AMIDO
AZABICYCLIC DERIVATIVES
STEREOSELECTIVE-SYNTHESIS
CYCLIZATION
Online AccessGet full text

Cover

More Information
Summary:Herein, we report the development of a novel route to tricyclic lactam products via a facile aza-[4 + 2] cycloaddition of catalytically generated acyliminium ions. Employing a Ca(NTf2)(2)/nBu(4)NPF(6) catalyst system in low loadings, a range of diverse fused ring systems can be synthesised in predominantly good yields.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob01663j