Differential expression of class I major histocompatibility complex determinants by lymphoblastic leukemia-lymphoma cell lines

Two T-cell lines (XR11-4T and XR11-5T), established from radiation-induced, murine lymphoblastic lymphomas, were examined for the expression of class I major histocompatibility complex antigen and tumor induction. These cell lines expressed class I private determinants, H-2.9 and H-2.26, but not the...

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Published inJNCI : Journal of the National Cancer Institute Vol. 82; no. 14; p. 1209
Main Authors Hester, R B, Rohrer, S D, Liu, P I, Coggin, Jr, J H
Format Journal Article
LanguageEnglish
Published United States 18.07.1990
Subjects
Animals
Epitopes - immunology
Genes, MHC Class I - immunology
Leukemia, Lymphoid - immunology
Leukemia, Radiation-Induced - immunology
Lymphoma, Non-Hodgkin - immunology
Mice
Mice, Inbred BALB C
Mice, Inbred Strains
Neoplasm Transplantation
Transplantation Immunology
Tumor Cells, Cultured - immunology
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Summary:Two T-cell lines (XR11-4T and XR11-5T), established from radiation-induced, murine lymphoblastic lymphomas, were examined for the expression of class I major histocompatibility complex antigen and tumor induction. These cell lines expressed class I private determinants, H-2.9 and H-2.26, but not the monomorphic determinant defined by monoclonal antibody M1/42. Both cell lines produced tumors in syngeneic and allogeneic hosts. The monomorphic determinant could be demonstrated on both cell lines following growth in allogeneic (BALB/c mice) but not in syngeneic (RFM mice) hosts. The re-expressed determinant present on cells following growth in allogeneic mice was not of host origin. Thus, tumorigenic x irradiation may differentially affect the expression of class I major histocompatibility complex determinants.
ISSN:0027-8874
DOI:10.1093/jnci/82.14.1209