Catheter ablation of atrial fibrillation in patients with left bundle branch block
Left bundle branch block (LBBB) and atrial fibrillation (AF) are commonly coexisting conditions. The impact of LBBB on catheter ablation of AF has not been well determined. This study aims to explore the long-term outcomes of patients with AF and LBBB after catheter ablation. Forty-two patients with...
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| Published in | Pacing and clinical electrophysiology Vol. 47; no. 4; pp. 518 - 524 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , |
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| Language | English |
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01.04.2024
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| Abstract | Left bundle branch block (LBBB) and atrial fibrillation (AF) are commonly coexisting conditions. The impact of LBBB on catheter ablation of AF has not been well determined. This study aims to explore the long-term outcomes of patients with AF and LBBB after catheter ablation.
Forty-two patients with LBBB of 11,752 patients who underwent catheter ablation of AF from 2011 to 2020 were enrolled as LBBB group. After propensity score matching in a 1:4 ratio, 168 AF patients without LBBB were enrolled as non-LBBB group. Late recurrence and a composite endpoint of stroke, all-cause mortality, and cardiovascular hospitalization were compared between the two groups.
Late recurrence rate was significantly higher in the LBBB group than that in the non-LBBB group (54.8% vs. 31.5%, p = .034). Multivariate analysis showed that LBBB was an independent risk factor for late recurrence after catheter ablation of AF (hazard ratio [HR] 2.19, 95% confidence interval [CI] 1.09-4.40, p = .031). LBBB group was also associated with a significantly higher incidence of the composite endpoint (21.4% vs. 6.5%, HR 3.98, 95% CI 1.64-9.64, p = .002).
LBBB was associated with a higher risk for late recurrence and a higher incidence of composite endpoint in the patients underwent catheter ablation. |
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| AbstractList | Left bundle branch block (LBBB) and atrial fibrillation (AF) are commonly coexisting conditions. The impact of LBBB on catheter ablation of AF has not been well determined. This study aims to explore the long-term outcomes of patients with AF and LBBB after catheter ablation.BACKGROUNDLeft bundle branch block (LBBB) and atrial fibrillation (AF) are commonly coexisting conditions. The impact of LBBB on catheter ablation of AF has not been well determined. This study aims to explore the long-term outcomes of patients with AF and LBBB after catheter ablation.Forty-two patients with LBBB of 11,752 patients who underwent catheter ablation of AF from 2011 to 2020 were enrolled as LBBB group. After propensity score matching in a 1:4 ratio, 168 AF patients without LBBB were enrolled as non-LBBB group. Late recurrence and a composite endpoint of stroke, all-cause mortality, and cardiovascular hospitalization were compared between the two groups.METHODSForty-two patients with LBBB of 11,752 patients who underwent catheter ablation of AF from 2011 to 2020 were enrolled as LBBB group. After propensity score matching in a 1:4 ratio, 168 AF patients without LBBB were enrolled as non-LBBB group. Late recurrence and a composite endpoint of stroke, all-cause mortality, and cardiovascular hospitalization were compared between the two groups.Late recurrence rate was significantly higher in the LBBB group than that in the non-LBBB group (54.8% vs. 31.5%, p = .034). Multivariate analysis showed that LBBB was an independent risk factor for late recurrence after catheter ablation of AF (hazard ratio [HR] 2.19, 95% confidence interval [CI] 1.09-4.40, p = .031). LBBB group was also associated with a significantly higher incidence of the composite endpoint (21.4% vs. 6.5%, HR 3.98, 95% CI 1.64-9.64, p = .002).RESULTSLate recurrence rate was significantly higher in the LBBB group than that in the non-LBBB group (54.8% vs. 31.5%, p = .034). Multivariate analysis showed that LBBB was an independent risk factor for late recurrence after catheter ablation of AF (hazard ratio [HR] 2.19, 95% confidence interval [CI] 1.09-4.40, p = .031). LBBB group was also associated with a significantly higher incidence of the composite endpoint (21.4% vs. 6.5%, HR 3.98, 95% CI 1.64-9.64, p = .002).LBBB was associated with a higher risk for late recurrence and a higher incidence of composite endpoint in the patients underwent catheter ablation.CONCLUSIONSLBBB was associated with a higher risk for late recurrence and a higher incidence of composite endpoint in the patients underwent catheter ablation. Left bundle branch block (LBBB) and atrial fibrillation (AF) are commonly coexisting conditions. The impact of LBBB on catheter ablation of AF has not been well determined. This study aims to explore the long-term outcomes of patients with AF and LBBB after catheter ablation. Forty-two patients with LBBB of 11,752 patients who underwent catheter ablation of AF from 2011 to 2020 were enrolled as LBBB group. After propensity score matching in a 1:4 ratio, 168 AF patients without LBBB were enrolled as non-LBBB group. Late recurrence and a composite endpoint of stroke, all-cause mortality, and cardiovascular hospitalization were compared between the two groups. Late recurrence rate was significantly higher in the LBBB group than that in the non-LBBB group (54.8% vs. 31.5%, p = .034). Multivariate analysis showed that LBBB was an independent risk factor for late recurrence after catheter ablation of AF (hazard ratio [HR] 2.19, 95% confidence interval [CI] 1.09-4.40, p = .031). LBBB group was also associated with a significantly higher incidence of the composite endpoint (21.4% vs. 6.5%, HR 3.98, 95% CI 1.64-9.64, p = .002). LBBB was associated with a higher risk for late recurrence and a higher incidence of composite endpoint in the patients underwent catheter ablation. BackgroundLeft bundle branch block (LBBB) and atrial fibrillation (AF) are commonly coexisting conditions. The impact of LBBB on catheter ablation of AF has not been well determined. This study aims to explore the long‐term outcomes of patients with AF and LBBB after catheter ablation.MethodsForty‐two patients with LBBB of 11,752 patients who underwent catheter ablation of AF from 2011 to 2020 were enrolled as LBBB group. After propensity score matching in a 1:4 ratio, 168 AF patients without LBBB were enrolled as non‐LBBB group. Late recurrence and a composite endpoint of stroke, all‐cause mortality, and cardiovascular hospitalization were compared between the two groups.ResultsLate recurrence rate was significantly higher in the LBBB group than that in the non‐LBBB group (54.8% vs. 31.5%, p = .034). Multivariate analysis showed that LBBB was an independent risk factor for late recurrence after catheter ablation of AF (hazard ratio [HR] 2.19, 95% confidence interval [CI] 1.09–4.40, p = .031). LBBB group was also associated with a significantly higher incidence of the composite endpoint (21.4% vs. 6.5%, HR 3.98, 95% CI 1.64–9.64, p = .002).ConclusionsLBBB was associated with a higher risk for late recurrence and a higher incidence of composite endpoint in the patients underwent catheter ablation. |
| Author | Ma, Chang‐Sheng Wu, Ze‐Yang Wang, Wei Zhao, Xin Lv, Wen‐He Liu, Xiao‐Ying Yu, Rong‐Hui Long, De‐Yong Wen, Song‐Nan Du, Zhuo‐Hang Wang, Xue‐Si Li, Song‐Nan Du, Xin He, Liu Jiang, Chen‐Xi Tang, Ri‐Bo Guo, Xue‐Yuan Dong, Jian‐Zeng Liu, Nian Sang, Cai‐Hua Li, Yu‐Kun |
| Author_xml | – sequence: 1 givenname: Ri‐Bo orcidid: 0000-0003-2812-1827 surname: Tang fullname: Tang, Ri‐Bo organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 2 givenname: Wen‐He surname: Lv fullname: Lv, Wen‐He organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 3 givenname: De‐Yong orcidid: 0000-0003-4604-5346 surname: Long fullname: Long, De‐Yong organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 4 givenname: Jian‐Zeng orcidid: 0000-0001-7299-7805 surname: Dong fullname: Dong, Jian‐Zeng organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 5 givenname: Xin surname: Du fullname: Du, Xin organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 6 givenname: Cai‐Hua surname: Sang fullname: Sang, Cai‐Hua organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 7 givenname: Rong‐Hui surname: Yu fullname: Yu, Rong‐Hui organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 8 givenname: Liu surname: He fullname: He, Liu organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 9 givenname: Chen‐Xi orcidid: 0000-0001-9131-0589 surname: Jiang fullname: Jiang, Chen‐Xi organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 10 givenname: Song‐Nan surname: Wen fullname: Wen, Song‐Nan organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 11 givenname: Nian surname: Liu fullname: Liu, Nian organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 12 givenname: Song‐Nan surname: Li fullname: Li, Song‐Nan organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 13 givenname: Wei surname: Wang fullname: Wang, Wei organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 14 givenname: Xue‐Yuan surname: Guo fullname: Guo, Xue‐Yuan organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 15 givenname: Xin orcidid: 0000-0003-3663-6097 surname: Zhao fullname: Zhao, Xin organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 16 givenname: Xiao‐Ying surname: Liu fullname: Liu, Xiao‐Ying organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 17 givenname: Ze‐Yang surname: Wu fullname: Wu, Ze‐Yang organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 18 givenname: Yu‐Kun surname: Li fullname: Li, Yu‐Kun organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 19 givenname: Xue‐Si surname: Wang fullname: Wang, Xue‐Si organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 20 givenname: Zhuo‐Hang surname: Du fullname: Du, Zhuo‐Hang organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China – sequence: 21 givenname: Chang‐Sheng orcidid: 0000-0002-5387-5957 surname: Ma fullname: Ma, Chang‐Sheng organization: Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China |
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| Cites_doi | 10.1016/j.jchf.2016.07.002 10.1002/joa3.12556 10.1093/eurheartj/ehaa612 10.1001/jama.2019.0693 10.1016/j.ijcard.2018.03.050 10.1161/CIRCEP.114.001479 10.1016/j.ijcard.2015.02.060 10.1016/j.ijcard.2013.07.250 10.1016/j.amjcard.2010.11.010 10.1007/s10840-019-00588-x 10.1016/j.ejheart.2006.11.006 10.1186/s12872-016-0308-1 10.1038/srep40828 10.1161/CIRCRESAHA.120.316340 10.1053/euhj.2001.3157 10.1067/mhj.2002.121264 10.1111/jce.13645 10.1002/clc.20714 10.1093/europace/euv067 |
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| Snippet | Left bundle branch block (LBBB) and atrial fibrillation (AF) are commonly coexisting conditions. The impact of LBBB on catheter ablation of AF has not been... BackgroundLeft bundle branch block (LBBB) and atrial fibrillation (AF) are commonly coexisting conditions. The impact of LBBB on catheter ablation of AF has... |
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| SubjectTerms | Ablation Cardiac arrhythmia Cardiovascular diseases Catheters Fibrillation Multivariate analysis Radiofrequency ablation Risk factors |
| Title | Catheter ablation of atrial fibrillation in patients with left bundle branch block |
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