Target-triggered dynamic hairpin assembly for signal amplification of microRNA and oncogenes and its application in live-cell imaging

Based on target-triggered dynamic hairpin assembly (DHA) in both unidirectional and bilateral growth manners DNA nanobrushes are constructed, which realize sensitive and selective detection of short miRNA (miR-21) and long DNA (BRCA1), respectively. Moreover, the unidirectional DHA strategy is readi...

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Published inChemical communications (Cambridge, England) Vol. 55; no. 28; pp. 4103 - 4106
Main Authors Li, Yuanfang, Yue, Shuzhen, Qi, Hongjie, Ding, Caifeng, Song, Weiling, Bi, Sai
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 02.04.2019
Subjects
Assembly
Deoxyribonucleic acid
DNA
Imaging
Ribonucleic acid
RNA
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Summary:Based on target-triggered dynamic hairpin assembly (DHA) in both unidirectional and bilateral growth manners DNA nanobrushes are constructed, which realize sensitive and selective detection of short miRNA (miR-21) and long DNA (BRCA1), respectively. Moreover, the unidirectional DHA strategy is readily applied to in situ imaging of miR-21 in different live cells.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc00747d