Narcolepsy and psychiatric disorders: A bidirectional Mendelian randomization study

Since the introduction of the concept of narcolepsy, there has been a proliferation of discussions about its association with psychiatry. To elucidate the causal role of narcolepsy in the three psychiatric disorders [i.e., schizophrenia (SCZ), major depressive disorder (MDD), and attention-deficit h...

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Published inJournal of psychiatric research Vol. 169; pp. 42 - 48
Main Authors Li, Biao, Gao, Zibo, He, Yue, Tian, Yuyang, Shen, Yuxuan, Yu, Ge, Geng, Xiaohan, Kou, Changgui
Format Journal Article
LanguageEnglish
Published England 01.01.2024
Subjects
Attention Deficit Disorder with Hyperactivity - complications
Depressive Disorder, Major - complications
Depressive Disorder, Major - epidemiology
Depressive Disorder, Major - genetics
Genome-Wide Association Study
Humans
Mendelian Randomization Analysis
Narcolepsy - complications
Narcolepsy - epidemiology
Narcolepsy - genetics
Narcolepsy
Mendelian randomization
Causality
Psychiatric disorder
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Summary:Since the introduction of the concept of narcolepsy, there has been a proliferation of discussions about its association with psychiatry. To elucidate the causal role of narcolepsy in the three psychiatric disorders [i.e., schizophrenia (SCZ), major depressive disorder (MDD), and attention-deficit hyperactivity disorder (ADHD)], we applied a bidirectional Mendelian randomization study using two stages (discovery stage and validation stage) and data from three different genome-wide association studies of narcolepsy. The estimates from different stages were combined using fixed-effects meta-analysis. Our findings suggest that narcolepsy is associated with an increased risk of SCZ. Conversely, MDD may be causally related to narcolepsy. A causal relationship between narcolepsy and ADHD was excluded.
Bibliography:ObjectType-Article-2
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content type line 23
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2023.11.034