Serological and biochemical study of hepatitis B patients, a report from the southeast of Iran

Clinical importance of HBeAg and HBeAb positivity was assessed in 309 patients with chronic HBV infection. Clinical, biochemical and serological data were extracted from medical archives over a 10-year period (2004-2014). HBeAg and HBeAb were positive in 46 (14.8%) and 221 (71.5%), respectively. Per...

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Bibliographic Details
Published inFuture virology Vol. 13; no. 2; pp. 103 - 110
Main Authors Shahramian, Iraj, Rostami, Daryoush, Sharafi, Elham, Sargazi-aval, Omolbanin, Delaramnasab, Mojtaba, Bazi, Ali
Format Journal Article
LanguageEnglish
Published London Future Medicine Ltd 01.02.2018
Subjects
Age
Antigens
aspartate aminotransferase
Blood & organ donations
Chronic infection
Endoscopy
Enzymes
Health risk assessment
Hepatitis
Hepatitis B
Hepatitis B e antigen
hepatitis B infection
Infections
Laboratories
Liver
liver diseases
Marital status
Patients
Population
Rural areas
Systematic review
Iran
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Summary:Clinical importance of HBeAg and HBeAb positivity was assessed in 309 patients with chronic HBV infection. Clinical, biochemical and serological data were extracted from medical archives over a 10-year period (2004-2014). HBeAg and HBeAb were positive in 46 (14.8%) and 221 (71.5%), respectively. Persistent elevation of AST and ALT enzymes were seen in 73 (21.2%) and 98 (30.1%) of the patients, respectively. HBeAb positivity rendered a significant protective effect against the elevated enzyme levels (odds ratio = 0.03; 95% CI: 0.003-000.3; p = 0.006 for AST, and odds ratio = 0.05; 95% CI: 0.007-000.4; p = 0.007 for ALT). Immune reaction against HbeAg in the course of chronic HBV infection rendered a protective factor against hepatic enzymes elevation.
ISSN:1746-0794
1746-0808
DOI:10.2217/fvl-2017-0102