PREPARATION OF CHITOSAN/HYDROXYAPATITE GUIDED MEMBRANE USED FOR PERIODONTAL TISSUE REGENERATION

• Published in: Chinese journal of polymer science Vol. 28; no. 4; pp. 555 - 561
• Main Authors: Zhang, Kai, Zhao, Man, Cai, Lei, Wang, Zheng-ke, Sun, Yong-fu, Hu, Qiao-ling
• Format: Journal Article
• Language: English
• Published: Heidelberg Chinese Chemical Society and Institute of Chemistry, CAS 01.07.2010
• Subjects: Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Condensed Matter Physics; Industrial Chemistry/Chemical Engineering; Polymer Sciences; 原位合成; 合成制备; 壳聚糖; 牙周组织再生; 牙周膜; 细胞毒性试验; 羟基磷灰石; Periodontal tissue regeneration; Hydroxyapatite; compositing; Chitosan membrane
• ISSN: 0256-7679; 1439-6203
• DOI: 10.1007/s10118-010-9087-9

In an effort to develop biomaterials to meet guided tissue regeneration （GTR） standards for periodontal tissue recovery, a homogeneous and transparent chitosan （CS）/hydroxyapatite （HA） membrane with potential applications as GTR barrier in periodontal therapy has been prepared via in situ compositing. The membrane has been designed to have a smoothrough asymmetric structure that meets the demand for GTR. Component and morphology of the membrane are characterized by XRD and SEM. It can be indicated that HA was in situ synthesized uniformly in the CS membrane. Mechanical experiments of the membranes with various HA contents show that their tensile strengths are adequate for periodontal therapy. Biological properties of the membrane have been performed by cell toxicity assays, hemolysis tests and animal experiments. Results indicate that the membrane has good biocompatibility and inductive effect for cell growth. Therefore this membrane can be potentially applied as GTR barrier membrane for periodontal tissue regeneration.