High-dose zolpidem abuse in a patient with insomnia comorbid with major depressive disorder

A 39-year-old married woman was referred to a psychiatry outpatient clinic for treatment of major depressive disorder (MDD). The dose of zolpidem she had been taking had increased to more than 500 mg/day and, therefore, she was hospitalized with the aim of zolpidem detoxification. On admission, her...

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Bibliographic Details
Published inSleep and biological rhythms Vol. 18; no. 2; pp. 155 - 157
Main Authors Furihata, Ryuji, Kizuki, Jun, Yamano, Yuya, Mizoguchi, Yasuhide, Nakajima, Suguru, Nagai, Kou, Kaneko, Yoshiyuki, Yamada, Koju, Suzuki, Masahiro, Uchiyama, Makoto
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.04.2020
Subjects
Biomedical and Life Sciences
Biomedicine
Case Report
Health Psychology
Human Physiology
Internal Medicine
Neurology
Neurosciences
Psychiatry
Zolpidem
Abuse
Insomnia
Major depressive disorders
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Summary:A 39-year-old married woman was referred to a psychiatry outpatient clinic for treatment of major depressive disorder (MDD). The dose of zolpidem she had been taking had increased to more than 500 mg/day and, therefore, she was hospitalized with the aim of zolpidem detoxification. On admission, her serum zolpidem level was 1550 ng/mL, and this dropped to less than one (ng/mL) within 50 h. However, after discontinuation of zolpidem, she experienced withdrawal symptoms. Though a few cases of high-dose zolpidem abuse have been reported in Japan, physicians should be aware that zolpidem has the potential for abuse and dependence.
ISSN:1446-9235
1479-8425
DOI:10.1007/s41105-019-00250-z