Anthracycline-based combined chemotherapy in the mouse model
Our research was aimed at establishing if and how selenium (Se) ion, N-acetylcysteine (NAC), sodium salt of monoketocholic acid (MKH) and superoxide-dismutase (SOD), administered in the experimental animal model, could affect the possible cytotoxicity associated with anthracycline-based combined che...
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| Published in | European journal of drug metabolism and pharmacokinetics Vol. 32; no. 2; pp. 101 - 108 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
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Médecine et hygiène
01.04.2007
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| Subjects | |
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| Abstract | Our research was aimed at establishing if and how selenium (Se) ion, N-acetylcysteine (NAC), sodium salt of monoketocholic acid (MKH) and superoxide-dismutase (SOD), administered in the experimental animal model, could affect the possible cytotoxicity associated with anthracycline-based combined chemotherapy with doxorubicin, vincristine and prednisolone (DVP). The following biochemical parameters were investigated: the extent of lipid peroxidation (LPx), and the activity of peroxidase (Px), catalase (CAT), glutathione-peroxidase (GSHPx), and xanthine-oxidase (XOD). A statistical increase in LPx activity was obtained by SOD, MKH, DVPSe and DVPMKH. All chemotherapeutic agents reduced Px activity in a statistically significant manner. There was no statistical significance for the results regarding the effects of the administered substances on GSHPx activity. The results for DVP, SOD, MKH, DVPSOD, DVPSe and DVPMKH showed reduced XOD activity which was statistically significant, which was lowest in the case of MKH, while NAC and Se reduced the activity of this enzyme but statistically non significant. NAC, Se, DVP, MKH and DVPMKH caused a reduction in CAT activity, while DVPSOD and DVPSe caused an increase of the latter. |
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| AbstractList | Our research was aimed at establishing if and how selenium (Se) ion, N-acetylcysteine (NAC), sodium salt of monoketocholic acid (MKH) and superoxide-dismutase (SOD), administered in the experimental animal model, could affect the possible cytotoxicity associated with anthracycline-based combined chemotherapy with doxorubicin, vincristine and prednisolone (DVP). The following biochemical parameters were investigated: the extent of lipid peroxidation (LPx), and the activity of peroxidase (Px), catalase (CAT), glutathione-peroxidase (GSHPx), and xanthine-oxidase (XOD). A statistical increase in LPx activity was obtained by SOD, MKH, DVPSe and DVPMKH. All chemotherapeutic agents reduced Px activity in a statistically significant manner. There was no statistical significance for the results regarding the effects of the administered substances on GSHPx activity. The results for DVP, SOD, MKH, DVPSOD, DVPSe and DVPMKH showed reduced XOD activity which was statistically significant, which was lowest in the case of MKH, while NAC and Se reduced the activity of this enzyme but statistically non significant. NAC, Se, DVP, MKH and DVPMKH caused a reduction in CAT activity, while DVPSOD and DVPSe caused an increase of the latter. |
| Author | KOLAROVIC, J TRIVIC, S KAURINOVIC, B MIKOV, M POPOVIC, M |
| Author_xml | – sequence: 1 givenname: M surname: POPOVIC fullname: POPOVIC, M organization: Faculty of Sciences, Department of Chemistry, University of Novi Sad, Serbia and Montenegro – sequence: 2 givenname: J surname: KOLAROVIC fullname: KOLAROVIC, J organization: Institute for Child and Youth Health Care, Department of Hematology/Oncology, Novi Sad, Serbia and Montenegro – sequence: 3 givenname: M surname: MIKOV fullname: MIKOV, M organization: School of Pharmacy, University of Otago, Dunedin, New Zealand – sequence: 4 givenname: S surname: TRIVIC fullname: TRIVIC, S organization: Faculty of Sciences, Department of Chemistry, University of Novi Sad, Serbia and Montenegro – sequence: 5 givenname: B surname: KAURINOVIC fullname: KAURINOVIC, B organization: Faculty of Sciences, Department of Chemistry, University of Novi Sad, Serbia and Montenegro |
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| CitedBy_id | crossref_primary_10_1016_j_fct_2010_04_007 crossref_primary_10_1007_s10616_014_9736_x crossref_primary_10_1016_j_chemosphere_2014_01_038 crossref_primary_10_3390_molecules14041627 crossref_primary_10_1016_j_fct_2014_07_022 crossref_primary_10_1016_j_fct_2019_110834 crossref_primary_10_3382_ps_pex127 crossref_primary_10_4236_jct_2015_61009 |
| Cites_doi | 10.1021/bi00344a014 10.1016/j.febslet.2004.10.053 10.1046/j.1440-1681.2003.03803.x 10.1021/tx015532n 10.1016/j.tox.2004.12.003 10.2165/00002018-199615060-00005 10.1016/0092-8674(93)90719-7 10.1089/105072504323030915 10.1016/S0021-9258(19)50881-X 10.1016/0092-8674(94)90518-5 10.1016/S0940-2993(11)80202-2 10.1080/10715760100301581 10.1016/0047-6374(96)01771-X 10.1016/S0016-5085(76)80318-6 10.1006/bbrc.1996.5898 10.1016/0021-9797(69)90181-7 10.1016/0006-2952(88)90176-1 10.1016/S0022-2275(20)38175-X 10.1023/A:1014862912783 10.3727/0965040042380450 10.1097/00001813-199402000-00001 10.1016/S0009-2797(02)00160-6 10.1093/carcin/6.12.1735 10.1016/S0015-3796(17)30073-2 10.1016/S1388-1981(99)00113-4 |
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| Keywords | Antineoplastic agent Animal model Digestive system Liver Rodentia antineoplastic anthracycline agents Vertebrata Mammalia Mouse Animal Animal model-mice Anthracyclins Combined treatment |
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| References_xml | – volume: 24 start-page: 6406 year: 1985 ident: BF03190998_CR2 publication-title: Biochemistry doi: 10.1021/bi00344a014 contributor: fullname: Y. Pommier – volume: 95 start-page: 3310 year: 2000 ident: BF03190998_CR23 publication-title: Blood contributor: fullname: M. Schrappe – volume: 577 start-page: 483 year: 2004 ident: BF03190998_CR31 publication-title: FEBS Lett. doi: 10.1016/j.febslet.2004.10.053 contributor: fullname: Y.M. Jang – volume: 30 start-page: 185 year: 2003 ident: BF03190998_CR36 publication-title: Clin. Exp. Pharmacol. Physiol. doi: 10.1046/j.1440-1681.2003.03803.x contributor: fullname: Q.Y. Liu – volume: 15 start-page: 1 year: 2002 ident: BF03190998_CR33 publication-title: Chem. Res. Toxicol. doi: 10.1021/tx015532n contributor: fullname: Y.J. Kang – volume: 209 start-page: 39 year: 2005 ident: BF03190998_CR11 publication-title: Toxicology doi: 10.1016/j.tox.2004.12.003 contributor: fullname: Y. Kalender – volume: 15 start-page: 406 year: 1996 ident: BF03190998_CR10 publication-title: Drug Safety doi: 10.2165/00002018-199615060-00005 contributor: fullname: R. Abraham – volume: 74 start-page: 957 year: 1993 ident: BF03190998_CR7 publication-title: Cell doi: 10.1016/0092-8674(93)90719-7 contributor: fullname: S.W. Lowe – volume: 14 start-page: 263 year: 2004 ident: BF03190998_CR3 publication-title: Thyroid doi: 10.1089/105072504323030915 contributor: fullname: C. Massart – volume: 195 start-page: 133 year: 1952 ident: BF03190998_CR27 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)50881-X contributor: fullname: R.F.J. Beers – volume-title: Methoden Der Enzymatischen Analyze year: 1970 ident: BF03190998_CR29 contributor: fullname: U.H. Bergmeyer – volume: 78 start-page: 539 year: 1994 ident: BF03190998_CR9 publication-title: Cell doi: 10.1016/0092-8674(94)90518-5 contributor: fullname: D.E. Fisher – volume: 44 start-page: 169 year: 1992 ident: BF03190998_CR12 publication-title: Exp. Toxicol. Pathol. doi: 10.1016/S0940-2993(11)80202-2 contributor: fullname: R. Dargel – volume: 35 start-page: 575 year: 2001 ident: BF03190998_CR34 publication-title: Free Radical Res. doi: 10.1080/10715760100301581 contributor: fullname: M.A. El-Missiry – volume: 90 start-page: 195 year: 1996 ident: BF03190998_CR14 publication-title: Mech. Ageing Dev. doi: 10.1016/0047-6374(96)01771-X contributor: fullname: K. Nakata – volume: 70 start-page: 1096 year: 1976 ident: BF03190998_CR22 publication-title: Gastroenterology doi: 10.1016/S0016-5085(76)80318-6 contributor: fullname: J.W. Dobbins – volume: 230 start-page: 254 year: 1997 ident: BF03190998_CR6 publication-title: Damage. Biochem. Biophys. Res. Commun doi: 10.1006/bbrc.1996.5898 contributor: fullname: I. Müller – volume: 31 start-page: 382 year: 1969 ident: BF03190998_CR21 publication-title: J. Colloid Interf. Sci. doi: 10.1016/0021-9797(69)90181-7 contributor: fullname: M.C. Carey – volume: 37 start-page: 881 year: 1988 ident: BF03190998_CR18 publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(88)90176-1 contributor: fullname: R.D. Issels – volume: 21 start-page: 633 year: 1991 ident: BF03190998_CR19 publication-title: G. Ital. Cardiol. contributor: fullname: F. Villani – volume: 23 start-page: 70 year: 1982 ident: BF03190998_CR20 publication-title: J. Lipid Res. doi: 10.1016/S0022-2275(20)38175-X contributor: fullname: M.J. Armstrong – volume: 90 start-page: 195 year: 1996 ident: BF03190998_CR15 publication-title: Mech. Ageing Dev. doi: 10.1016/0047-6374(96)01771-X contributor: fullname: K. Nakata – volume: 232 start-page: 19 year: 2002 ident: BF03190998_CR30 publication-title: Mol. Cell. Biochem. doi: 10.1023/A:1014862912783 contributor: fullname: T. Li – volume: 14 start-page: 469 year: 2004 ident: BF03190998_CR32 publication-title: Oncol. 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Buege – volume: 166 start-page: 387 year: 1974 ident: BF03190998_CR26 publication-title: Biochem. Physiol. Pflanzen. doi: 10.1016/S0015-3796(17)30073-2 contributor: fullname: L. M. Simon – volume: 445 start-page: 558 year: 1976 ident: BF03190998_CR28 publication-title: Biophys. Acta contributor: fullname: D.T.Y. Chiu – volume: 20 start-page: 949 year: 2002 ident: BF03190998_CR4 publication-title: Int. J. Oncol. contributor: fullname: X.X. Wu – volume: 35 start-page: 65 year: 1981 ident: BF03190998_CR1 publication-title: Biomedicine contributor: fullname: F. Maccari – volume: 60 start-page: 2912 year: 2000 ident: BF03190998_CR5 publication-title: Cancer Res. contributor: fullname: X.X. Wu – volume: 1440 start-page: 100 year: 1999 ident: BF03190998_CR13 publication-title: Biochim. Biophys. Acta doi: 10.1016/S1388-1981(99)00113-4 contributor: fullname: A. Bordoni |
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| SubjectTerms | Acetylcysteine - pharmacology Analysis of Variance Animals Anthracyclines - administration & dosage Anthracyclines - adverse effects Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antioxidants - pharmacology Biological and medical sciences Catalase - drug effects Cholic Acids - pharmacology Doxorubicin - administration & dosage Doxorubicin - adverse effects Drug Interactions Free Radical Scavengers - pharmacology Glutathione Peroxidase - drug effects Heart - drug effects Lipid Peroxidation - drug effects Liver - drug effects Medical sciences Mice Mice, Inbred BALB C Peroxidase - drug effects Pharmacology. Drug treatments Prednisolone - administration & dosage Prednisolone - adverse effects Selenium - pharmacology Superoxide Dismutase - pharmacology Vincristine - administration & dosage Vincristine - adverse effects Xanthine Oxidase - drug effects |
| Title | Anthracycline-based combined chemotherapy in the mouse model |
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