Anthracycline-based combined chemotherapy in the mouse model

• Published in: European journal of drug metabolism and pharmacokinetics Vol. 32; no. 2; pp. 101 - 108
• Main Authors: POPOVIC, M, KOLAROVIC, J, MIKOV, M, TRIVIC, S, KAURINOVIC, B
• Format: Journal Article
• Language: English
• Published: Genève Médecine et hygiène 01.04.2007
• Subjects: Acetylcysteine - pharmacology; Analysis of Variance; Animals; Anthracyclines - administration & dosage; Anthracyclines - adverse effects; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Antioxidants - pharmacology; Biological and medical sciences; Catalase - drug effects; Cholic Acids - pharmacology; Doxorubicin - administration & dosage; Doxorubicin - adverse effects; Drug Interactions; Free Radical Scavengers - pharmacology; Glutathione Peroxidase - drug effects; Heart - drug effects; Lipid Peroxidation - drug effects; Liver - drug effects; Medical sciences; Mice; Mice, Inbred BALB C; Peroxidase - drug effects; Pharmacology. Drug treatments; Prednisolone - administration & dosage; Prednisolone - adverse effects; Selenium - pharmacology; Superoxide Dismutase - pharmacology; Vincristine - administration & dosage; Vincristine - adverse effects; Xanthine Oxidase - drug effects; Antineoplastic agent; Animal model; Digestive system; Liver; Rodentia; antineoplastic anthracycline agents; Vertebrata; Mammalia; Mouse; Animal; Animal model-mice; Anthracyclins; Combined treatment
• ISSN: 0378-7966; 2107-0180
• DOI: 10.1007/BF03190998

Our research was aimed at establishing if and how selenium (Se) ion, N-acetylcysteine (NAC), sodium salt of monoketocholic acid (MKH) and superoxide-dismutase (SOD), administered in the experimental animal model, could affect the possible cytotoxicity associated with anthracycline-based combined chemotherapy with doxorubicin, vincristine and prednisolone (DVP). The following biochemical parameters were investigated: the extent of lipid peroxidation (LPx), and the activity of peroxidase (Px), catalase (CAT), glutathione-peroxidase (GSHPx), and xanthine-oxidase (XOD). A statistical increase in LPx activity was obtained by SOD, MKH, DVPSe and DVPMKH. All chemotherapeutic agents reduced Px activity in a statistically significant manner. There was no statistical significance for the results regarding the effects of the administered substances on GSHPx activity. The results for DVP, SOD, MKH, DVPSOD, DVPSe and DVPMKH showed reduced XOD activity which was statistically significant, which was lowest in the case of MKH, while NAC and Se reduced the activity of this enzyme but statistically non significant. NAC, Se, DVP, MKH and DVPMKH caused a reduction in CAT activity, while DVPSOD and DVPSe caused an increase of the latter.