Secretion of empty or complete hepatitis B virions: envelopment of empty capsids versus mature nucleocapsids

HBV replicates its DNA genome, a partially double-stranded, relaxed circular DNA, via reverse transcription of an RNA intermediate called pre-genomic RNA by its reverse transcriptase. A major characteristic of HBV replication is the selective envelopment and secretion of relaxed circular DNA-contain...

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Bibliographic Details
Published inFuture virology Vol. 14; no. 2; pp. 95 - 105
Main Authors Liu, Kuancheng, Hu, Jianming
Format Journal Article
LanguageEnglish
Published London Future Medicine Ltd 01.02.2019
Subjects
Antigens
capsid
Capsids
Circular DNA
complete virion
Deoxyribonucleic acid
DNA
DNA biosynthesis
empty virion
Genomes
Hepatitis
Hepatitis B
hepatitis B virus
Hepatitis delta virus
Interferon
Morphogenesis
Nucleocapsids
Proteins
Replication
Reverse transcription
Ribonucleic acid
RNA
RNA-directed DNA polymerase
Secretion
Single-stranded DNA
Virions
Virology
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Summary:HBV replicates its DNA genome, a partially double-stranded, relaxed circular DNA, via reverse transcription of an RNA intermediate called pre-genomic RNA by its reverse transcriptase. A major characteristic of HBV replication is the selective envelopment and secretion of relaxed circular DNA-containing mature capsids and empty capsids with no DNA or RNA, but not those containing pre-genomic RNA or the single-stranded DNA replication intermediate. In this review, the potential mechanisms of HBV virion morphogenesis will be discussed, with a focus on key determinants of both the capsid and envelope proteins for the selective secretion of complete and empty virions.
ISSN:1746-0794
1746-0808
DOI:10.2217/fvl-2018-0128