A chemoselective cleavable fluorescence turn-ON linker for proteomic studies

We have developed a trifunctional cleavable fluorescence turn-ON linker for chemoproteomic applications. This novel linker, which became highly fluorescent only upon cleavage of the azo bond, was successfully used for in situ proteome profiling/target identification and studies on newly synthesised...

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Published inChemical communications (Cambridge, England) Vol. 53; no. 100; pp. 13332 - 13335
Main Authors Liew, Si Si, Du, Shubo, Ge, Jingyan, Pan, Sijun, Jang, Se-Young, Lee, Jun-Seok, Yao, Shao Q.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 2017
Royal Society of Chemistry
Subjects
Chemistry
Chemistry, Multidisciplinary
Fluorescence
Physical Sciences
Science & Technology
Target recognition
SYSTEM
STREPTAVIDIN
CHEMICAL PROTEOMICS
BIOLOGY
CHEMISTRY
TARGETS
LIVE CELLS
PROBES
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Summary:We have developed a trifunctional cleavable fluorescence turn-ON linker for chemoproteomic applications. This novel linker, which became highly fluorescent only upon cleavage of the azo bond, was successfully used for in situ proteome profiling/target identification and studies on newly synthesised proteomes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc08235e