[60]Fullerenyl amino acids and peptides: a review of their synthesis and applications
This review reports on the latest progress in the synthesis of fullerenyl amino acids and related derivatives, and categorises the molecules into functional types for different uses: these include directly attached fullerenyl amino acids, fullerenyl N- and C-capping amino acids, and those amino acid...
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| Published in | RSC advances Vol. 4; no. 86; pp. 46383 - 46398 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
01.01.2014
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| Online Access | Get full text |
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| Summary: | This review reports on the latest progress in the synthesis of fullerenyl amino acids and related derivatives, and categorises the molecules into functional types for different uses: these include directly attached fullerenyl amino acids, fullerenyl N- and C-capping amino acids, and those amino acids in which the [60]fullerene group is attached to the amino acid side chain. These first and last mentioned derivatives have the potential to be incorporated into non-terminal positions of peptides. The applications of these substrates, by integration into different biological and materials chemistry programs, are also highlighted.
This review reports on the latest progress in the synthesis of fullerenyl amino acids and related derivatives, and categorises the molecules into functional types for different uses: these include directly attached fullerenyl amino acids, fullerenyl N- and C-capping amino acids, and those amino acids in which the [60]fullerene group is attached to the amino acid side chain. |
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| Bibliography: | Prof. Stephen Pyne received his PhD in 1979 from the Australian National University under the supervision of Prof. Lew Mander, working on the chemical synthesis of the plant growth hormone, gibberellic acid. After postdoctoral research fellowships at Purdue University (with P. Fuchs) and Harvard (with E.J. Corey) he started his first academic appointment as a lecturer at the University of Wollongong in 1985. In 2008 he was appointed to Professor of Chemistry. He was the Young Researcher of the Year for 1992 (offered by the Australian Research Council and the von Humboldt Foundation), a Rhone Poulenc Fellow (1994), an ARC Senior Fellow (1994-1998) and won the A.J. Birch Medal for excellence in Organic Chemistry Research, from the Organic Division of the Royal Australian Chemical Institute in 2012. His main areas of research include, natural product synthesis (especially alkaloids), phytochemistry (including plants from SE Asia), the discovery of new methods for the synthesis of heterocycles, fullerene chemistry and antibacterial drug discovery. Assoc. Prof. Paul Keller completed his BSc(Hons) (1985) and PhD at the University of New South Wales, Australia, before undertaking an Alexander von Humboldt funded post-doctoral fellowship at the University of Wuerzburg, Germany, working in collaboration with Gerhard Bringmann. Since 1994, he has worked at the University of Wollongong, Australia, and is currently Associate Professor in Organic and Medicinal Chemistry. His interests lie in the drug design and development of new generation anti-infectives with a particular emphasis on new generation anti-bacterials and anti-virals, new chemistry of indigo, chiral ligand design for sterically hindered reactions and new fullerene chemistry. Sreenu Jennepalli was born in Burahanpally, in the Warangal district of Telangana, India. He has received a B. Sc degree from Kakatiya University in 1998 and M.Sc (Organic Chemistry) from Osmania University in 2001, before joining Dr Reddy's Research Foundation (DRF), Drug Discovery, Discovery Chemistry, Miyapur, Hyderabad, India. He worked on various projects including Anti-cancer, Metabolic disorders and Cardiovascular diseases from 2001-2008 as Associate Scientist, after which he moved to Hetero Drugs Pty Ltd, Hyderabad, India, working as a Team Leader-Scientist in New Drug Discovery from 2008-2010, on Antivirals and Metabolic disorders. In 2010, he undertook a PhD candidature at the University of Wollongong, Australia, working under the supervision of Assoc. Prof. Paul A. Keller and Prof. Stephen G. Pyne. His research interests are [60]fullerene chemistry, medicinal chemistry, synthesis of heterocycles and total synthesis of natural products. |
| ISSN: | 2046-2069 2046-2069 |
| DOI: | 10.1039/c4ra07310j |