Perfusion of nonventilated lung: failure of hypoxic vasoconstriction?

Alveolar hypoxia is a well established cause of regional vasoconstriction such that nonventilated segments are not perfused. The paradoxical situation of retained perfusion of nonventilated lung has seldom been discussed. Three clinical examples are illustrated. In each case coexistent chronic obstr...

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Bibliographic Details
Published inAmerican journal of roentgenology (1976) Vol. 141; no. 1; pp. 151 - 156
Main Authors Sostman, H D, Neumann, R D, Gottschalk, A, Greenspan, R H
Format Journal Article
LanguageEnglish
Published United States 01.07.1983
Subjects
Aged
Female
Humans
Hypoxia - physiopathology
Lung - diagnostic imaging
Lung Diseases, Obstructive - diagnostic imaging
Lung Diseases, Obstructive - physiopathology
Male
Methods
Middle Aged
Perfusion
Pulmonary Alveoli - physiopathology
Radionuclide Imaging
Vasoconstriction
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Summary:Alveolar hypoxia is a well established cause of regional vasoconstriction such that nonventilated segments are not perfused. The paradoxical situation of retained perfusion of nonventilated lung has seldom been discussed. Three clinical examples are illustrated. In each case coexistent chronic obstructive lung disease may have contributed to this unexpected finding by reducing pulmonary vascular capacity such that blood flow diversion from hypoxic segments was not possible.
Bibliography:ObjectType-Case Study-3
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-2
ISSN:0361-803X
1546-3141
DOI:10.2214/ajr.141.1.151