Deleterious iron-mediated oxidation of biomolecules

Iron is an essential metal for most biological organisms. However, if not tightly controlled, iron can mediate the deleterious oxidation of biomolecules. This review focuses on the current understanding of the role of iron in the deleterious oxidation of various biomolecules, including DNA, protein,...

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Bibliographic Details
Published inFree Radical Biology and Medicine Vol. 32; no. 7; pp. 577 - 583
Main Authors Welch, Kevin D, Davis, T.Zane, Van Eden, Marc E, Aust, Steven D
Format Book Review Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2002
Subjects
Animals
Ascorbic Acid - metabolism
Biomolecule oxidation
Ceruloplasmin
DNA - metabolism
Ferritin
Ferritins - metabolism
Free radicals
Humans
Iron
Iron - physiology
Lipid Metabolism
Macromolecular Substances
Oxidation-Reduction
Proteins - metabolism
Ceruloplasmin
Iron
Free radicals
Biomolecule oxidation
Ferritin
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Summary:Iron is an essential metal for most biological organisms. However, if not tightly controlled, iron can mediate the deleterious oxidation of biomolecules. This review focuses on the current understanding of the role of iron in the deleterious oxidation of various biomolecules, including DNA, protein, lipid, and small molecules, e.g., ascorbate and biogenic amines. The effect of chelation on the reactivity of iron is also addressed, in addition to iron-associated toxicities. The roles of the iron storage protein ferritin as both a source of iron for iron-mediated oxidations and as a mechanism to safely store iron in cells is also addressed.
ISSN:0891-5849
1873-4596
DOI:10.1016/S0891-5849(02)00760-8