Caveolae: From Cell Biology to Animal Physiology

Among the membrane compartments of a cell, vesicles known as “caveolae” have long defied functional characterization. However, since the identification of a family of proteins termed “caveolins”, that form and reside in caveolae, a better understanding has emerged. It is now clear that caveo...

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Published inPharmacological reviews Vol. 54; no. 3; pp. 431 - 467
Main Authors Razani, Babak, Woodman, Scott E, Lisanti, Michael P
Format Journal Article
LanguageEnglish
Published United States American Society for Pharmacology and Experimental Therapeutics 01.09.2002
Subjects
Animals
Caveolae - physiology
Caveolae - ultrastructure
Caveolins - genetics
Caveolins - physiology
Cell Membrane - physiology
Cholesterol - metabolism
Disease Models, Animal
Evolution, Molecular
Humans
Mice
Mutation
Neoplasms - genetics
Oncogenes - physiology
Signal Transduction
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Summary:Among the membrane compartments of a cell, vesicles known as “caveolae” have long defied functional characterization. However, since the identification of a family of proteins termed “caveolins”, that form and reside in caveolae, a better understanding has emerged. It is now clear that caveolae do not merely play a singular role in the cell, but are pleiotropic in nature—serving to modulate many cellular functions. The purpose of this review is to explicate what is known about caveolins/caveolae and highlight growing areas of caveolar research.
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ISSN:0031-6997
1521-0081
DOI:10.1124/pr.54.3.431