Identification of Giardia lamblia Assemblage E in Humans Points to a New Anthropozoonotic Cycle

Giardia lamblia is a pathogen transmitted by water and food that causes infection worldwide. Giardia genotypes are classified into 8 assemblages (A-H). Assemblages A and are detected in humans, but they are potentially zoonotic because they infect other mammalian hosts. Giardia in samples from 44 ch...

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Published inThe Journal of infectious diseases Vol. 214; no. 8; pp. 1256 - 1259
Main Authors Fantinatti, Maria, Bello, Alexandre R., Fernandes, Octavio, Da-Cruz, Alda M.
Format Journal Article
LanguageEnglish
Published United States Oxford University Press 15.10.2016
Subjects
Animals
Child, Preschool
DNA, Protozoan - genetics
Genotype
Giardia lamblia - genetics
Giardiasis - parasitology
Glutamate Dehydrogenase - genetics
Humans
Infant
PARASITES
Phylogeny
Protozoan Proteins - genetics
Sequence Alignment
β-giardin gene
Giardia lamblia
molecular characterization
assemblage E
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Summary:Giardia lamblia is a pathogen transmitted by water and food that causes infection worldwide. Giardia genotypes are classified into 8 assemblages (A-H). Assemblages A and are detected in humans, but they are potentially zoonotic because they infect other mammalian hosts. Giardia in samples from 44 children was genotyped. Conserved fragments of the genes encoding β-giardin and glutamate dehydrogenase were sequenced and their alignment were carried out with sequences deposited in GenBank. As expected for Rio de Janeiro, the majority of samples were related to assemblage A. Surprisingly, assemblage E was detected in 15 samples. Detection of assemblage E in humans suggests a new zoonotic route of Giardia transmission.
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ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiw361