Manganese-doped stellate mesoporous silica nanoparticles: A bifunctional nanoplatform for enhanced chemodynamic therapy and tumor imaging

• Published in: Microporous and mesoporous materials Vol. 370; p. 113012
• Main Authors: Qin, Guoqiang, Xie, Wenjie, Luo, Xin, Zou, Ge, Mo, Qishan, Zhong, Weide
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.04.2024
• Subjects: Chemodynamic therapy; Mesoporous; Nanoparticles; Prostate cancer; Nanoparticles; Chemodynamic therapy; Mesoporous; Prostate cancer
• ISSN: 1387-1811; 1873-3093
• DOI: 10.1016/j.micromeso.2024.113012

This study reports an effective and facile strategy for developing multifunctional nanoplatforms by the in situ doping of manganese metal into stellate mesoporous silica nanoparticles (Mn-SMSN). The resulting Mn-SMSN@DOX-IR-780 effectively integrated enhanced chemodynamic therapy (CDT) combined with tumor imaging in a single platform after additional loading of doxorubicin hydrochloride (DOX) and IR-780 iodide (IR-780) onto Mn-SMSN. Mn-SMSN@DOX-IR-780 demonstrated excellent in vitro efficacy in killing cancer cells and inhibiting cancer cell migration and invasion. Further mechanistic investigations demonstrated that Mn-SMSN@DOX-IR-780 effectively promoted the production of cytotoxic reactive oxygen species to kill tumor cells. Moreover, Mn-SMSN@DOX-IR-780 efficiently delivered DOX and IR-780 into cells, indicating potential for chemodynamic therapy and tumor imaging. In summary, the developed Mn-SMSN@DOX-IR-780 integrated CDT and image guidance, which can provide insights for future biomedical research applications concerning efficient prostate cancer treatment. [Display omitted] •Mn-SMSN@DOX-IR-780 is developed by in situ doping of manganese metal into Mn-SMSN.•Chemodynamic therapy (CDT) is integrated with tumor imaging by Mn-SMSN@DOX-IR-780.•This is achieved by loading of doxorubicin hydrochloride and IR-780 iodide onto Mn-SMSN.•Mn-SMSN@DOX-IR-780 promoted cytotoxic reactive oxygen species to kill tumor cells.•CDT and image guidance integration can provide insights for prostate cancer treatment.