Familial restless legs with periodic movements in sleep: electrophysiologic, biochemical, and pharmacologic study

Restless legs syndrome was present in nine members of a family over a span of five generations. In three subjects, the diagnosis was confirmed by all-night sleep recordings and concomitant EMG. Two of these three subjects also had periodic movements in sleep. The frequency of leg movements decreased...

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Bibliographic Details
Published inNeurology Vol. 35; no. 1; p. 130
Main Authors Montplaisir, J, Godbout, R, Boghen, D, DeChamplain, J, Young, S N, Lapierre, G
Format Journal Article
LanguageEnglish
Published United States 01.01.1985
Subjects
Adult
Biogenic Amines - analysis
Clonazepam - therapeutic use
Electrophysiology
Female
Humans
Male
Restless Legs Syndrome - drug therapy
Restless Legs Syndrome - genetics
Restless Legs Syndrome - metabolism
Restless Legs Syndrome - physiopathology
Sleep
Wakefulness
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Summary:Restless legs syndrome was present in nine members of a family over a span of five generations. In three subjects, the diagnosis was confirmed by all-night sleep recordings and concomitant EMG. Two of these three subjects also had periodic movements in sleep. The frequency of leg movements decreased from wakefulness to stages 1 and 2 non-REM sleep. There was an increase of free dopamine and homovanillic acid in CSF of the propositus. Clonazepam effectively controlled restless legs in the propositus and his mother.
ISSN:0028-3878
DOI:10.1212/WNL.35.1.130