Immune mechanisms in beryllium lung disease

The role of the immune system in the pathogenesis of beryllium lung disease has been suspected for years. The observation of cutaneous hypersensitivity to beryllium led to the development of the lymphocyte blast transformation test; the test clearly distinguishes between healthy subjects, who show l...

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Bibliographic Details
Published inCleveland Clinic journal of medicine Vol. 58; no. 2; p. 157
Main Authors Deodhar, S D, Barna, B P
Format Journal Article
LanguageEnglish
Published United States 01.03.1991
Subjects
Animals
Berylliosis - diagnosis
Berylliosis - immunology
Beryllium - toxicity
Chemical Industry
Granulomatous Disease, Chronic - chemically induced
Granulomatous Disease, Chronic - diagnosis
Guinea Pigs
Humans
Lymphocyte Activation
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Summary:The role of the immune system in the pathogenesis of beryllium lung disease has been suspected for years. The observation of cutaneous hypersensitivity to beryllium led to the development of the lymphocyte blast transformation test; the test clearly distinguishes between healthy subjects, who show little or no blast transformation response, and patients with beryllium lung disease, who demonstrate significant responses. The degree of blast transformation also correlates with the severity of the clinical disease. Animal studies have demonstrated the importance of histocompatibility antigens in development of the disease, and support the participation of cellular immune mechanisms.
ISSN:0891-1150
DOI:10.3949/ccjm.58.2.157