Protective effects of Resveratrol in an experimental model of abdominal aortic aneurysm induction

Resveratrol (Rsv) is a natural antioxidant polyphenol with vasoprotective properties. We evaluated whether Rsv affects the inflammatory response in an experimental model of elastase-induced abdominal aortic aneurysm. Thirty male rats were subjected to aneurysm induction and treated or not with Rsv....

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Bibliographic Details
Published inJournal of Biological Research Vol. 84; no. 1; p. 122
Main Authors Palmieri, D., Barisione, C., Pane, C, Spinella, G., Garibaldi, S., Ghigliotti, G., Brunelli, C., Fulcheri, E., Palombo, D.
Format Journal Article
LanguageEnglish
Italian
Published Pavia PAGEPress Publications 01.01.2011
Subjects
Andominal aortic aneurysm, Monocytes, MMPs, TNF-α
Aneurysms
Antioxidants
Aortic aneurysms
Elastase
Gelatinase B
Immune response
Inflammation
L-selectin
Monocytes
Resveratrol
Serum levels
Tumor necrosis factor-α
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Summary:Resveratrol (Rsv) is a natural antioxidant polyphenol with vasoprotective properties. We evaluated whether Rsv affects the inflammatory response in an experimental model of elastase-induced abdominal aortic aneurysm. Thirty male rats were subjected to aneurysm induction and treated or not with Rsv. Circulating levels of CD62L-monocyte subset, monocyte CD I 43 surface expression, MMP-9 plasma activity and TNFα serum levels were lower in Rsv-treated rats. In conclusion. Rsv acts as an anti-inflammatory compound and could be of great revelance to improve the immune response in AAA patients.
ISSN:1826-8838
2284-0230
DOI:10.4081/jbr.2011.4638