Efficacy of ERL-4221 as an ovotoxin for feral pigs (Sus scrofa)

• Published in: Wildlife research (East Melbourne) Vol. 38; no. 2; pp. 168 - 172
• Main Authors: Sanders, Dustin L, Xie, Fang, Mauldin, Richard E, Hurley, Jerome C, Miller, Lowell A, Garcia, Michelle R, DeYoung, Randy W, Long, David B, Campbell, Tyler A
• Format: Journal Article
• Language: English
• Published: Collingwood, Victoria: CSIRO Publishing 01.01.2011
• Subjects: antifertility effect; epoxides; feral animals; follicular development; oocytes; oral administration; ovaries; ovulation; resins; Sus scrofa; swine; toxicity; wildlife damage management; wildlife management
• ISSN: 1035-3712; 1448-5494
• DOI: 10.1071/WR10179

Context The expansion of feral pig populations across the United States has increased the occurrence of damage and damage complaints. New techniques are needed to more effectively manage feral pig damage, including the development of fertility control agents. Aims We aimed to assess the ovotoxic properties of ERL-4221 as a candidate fertility control agent for feral pigs. Methods We conducted two palatability trials to determine ERL-4221 acceptance and one experimental trial with ERL-4221 at the captive wildlife facility of Texas A&M University-Kingsville during 2008. Our experimental trial had three treatments, a control containing no ERL-4221, baits containing 16.0mg ERL-4221kg⁻¹ bodyweight for 10 days, and baits containing 16.0mg ERL-4221kg⁻¹ bodyweight for 20 days. Key results Final body mass, total ovary mass, number of follicles and number of corpora lutea did not differ between treatments. Conclusions We did not find it efficacious to orally deliver ERL-4221 to feral pigs to reduce fertility. Oral delivery is the most practical, cost-effective means of delivering fertility control agents to feral pigs and development of additional fertility control strategies are needed. Implications Unless ovotoxic effects of ERL-4221 can be identified in feral pigs, along with a successful means of administration, other fertility control strategies may need to be explored, such as oocyte-secreted proteins that regulate follicular development.