Egg yolk immunoglobulins' impact on experimental periodontitis caused by Porphyromonas gingivalis

• Published in: Technology and health care Vol. 26; no. 5; pp. 805 - 814
• Main Authors: Wang, Fang, Qiao, Wu, Xu, Xiaochen, Wang, Shujun, Regenstein, Joe M, Bao, Bin, Ma, Ming
• Format: Journal Article
• Language: English
• Published: Netherlands IOS Press BV 01.01.2018
• Subjects: Alveolar bone; Alveolar Bone Loss - drug therapy; Animals; Bleeding; Bone loss; Dental Plaque Index; Disease Models, Animal; Gingival index; Gum disease; Histology; Immunoglobulins; Immunoglobulins - pharmacology; Inflammation Mediators - metabolism; Interleukin 6; Interleukin-6 - biosynthesis; Molars; Oral cavity; Periodontal Index; Periodontitis; Periodontitis - drug therapy; Periodontitis - physiopathology; Plaque index; Porphyromonas gingivalis; Porphyromonas gingivalis - drug effects; Radiography; Rats; Silk; Sodium chloride; Teeth; Tumor necrosis factor; Tumor Necrosis Factor-alpha - biosynthesis; X-ray radiography; Yolk; Porphyromonas gingivalis; egg yolk immunoglobulins; IgY; Periodontitis; TNF-α; IL-6
• ISSN: 0928-7329; 1878-7401
• DOI: 10.3233/THC-181255

Periodontitis is a chronic inflammatory disease caused by Porphyromonas gingivalis that leads to a series of periodontal tissue injuries. Egg yolk immunoglobulins (IgY) is procuded in egg yolk and inhibits P. gingivalis. The aim was to evaluate the effect of IgY on experimental periodontitis caused by P. gingivalis. The second molars of rats were ligatured using medical 5-0 silk and smeared with P. gingivalis to induce experimental periodontitis. Then, the rats were smeared with 2 mL IgY solutions or 0.9% NaCl in the oral cavity for up to 4 wk. The scores for gingival index, plaque index and probe on bleeding, the levels of IL-6 and TNF-α, X-ray radiography and histology were used to determine the efficacy of the IgY on experimental periodontitis. The clinical indices improved; the levels of IL-6 and TNF-α were significantly (p< 0.05) decreased; the X-rays and histomorphological observations suggested that the periodontal inflammation and periodontitis were alleviated compared to the control. IgY showed significant effects on anti-inflammatory, anti-coaggregation activity, and protected against alveolar bone loss. Therefore, it had a beneficial effect on preventing experimental periodontitis caused by P. gingivalis.