Mesoporous hollow hydroxyapatite capped with smart polymer for multi-stimuli remotely controlled drug delivery

• Published in: Microporous and mesoporous materials Vol. 306; p. 110447
• Main Authors: Chen, Ruixia, Shi, Jun, Zhu, Beibei, Zhang, Li, Cao, Shaokui
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 15.10.2020
• Subjects: Gold nanorods; Hydroxyapatite; Microcapsules; Poly(N-isopropylacrylamide-co-acrylic acid); Thermal-/pH-/NIR-responsiveness; Thermal-/pH-/NIR-responsiveness; Microcapsules; Poly(N-isopropylacrylamide-co-acrylic acid); Hydroxyapatite; Gold nanorods
• ISSN: 1387-1811; 1873-3093
• DOI: 10.1016/j.micromeso.2020.110447

In this paper, a pH-/thermal-/NIR multi-responsive drug delivery platform based on hollow hydroxyapatite (H-HAP), poly(N-isopropylacrylamide- co-acrylic acid) (PNA) and gold nanorods (AuNRs) were prepared via electrostatic self-assembly. Thermal-sensitive PNA and near-infrared (NIR) responsive AuNRs were capped on the surface of mesoporous hollow HAP to obstruct the initial burst release of HAP and endow the vehicles with multi-responsive drug delivery properties. Notable pH-/thermal-/NIR multi-responsive drug release properties were clearly observed for H-HAP/PNA/AuNRs hybrid microcapsules. In addition, relatively high DOX release could be found for H-HAP/PNA/AuNRs hybrid microcapsules at pH 4.5 upon NIR laser irradiation, due to the corrosion of H-HAP in acidic media and the synergistically photothermal effect between AuNRs and PNA. This study provides a feasible method to fabricate intelligently controllable hybrid drug carriers, which shows great potential in controllable drug delivery. Mesoporous hollow hydroxyapatite capped with smart polymer and AuNRs for multi-responsive drug delivery was fabricated via electrostatic self-assembly. [Display omitted] •Hollow hierarchical HAP/PNA/AuNRs hybrids were prepared.•PNA and AuNRs were capped on the surface of mesoporous hollow HAP.•DOX existed between H-HAP and PNA via electrostatic interaction.•Hollow hybrids exhibited pH-/thermal-/NIR multi-responsiveness.•Synergistically photothermal effect was obtained from hollow hybrids.