3D printing technology: A new approach for the fabrication of personalized and customized pharmaceuticals

• Published in: European polymer journal Vol. 195; p. 112240
• Main Authors: Ullah, Muneeb, Wahab, Abdul, Khan, Shahid Ullah, Naeem, Muhammad, ur Rehman, Khalil, Ali, Haider, Ullah, Aziz, Khan, Amjad, Khan, Nauman Rahim, Rizg, Waleed Y., Hosny, Khaled M., Alissa, Mohammed, Badr, Moutaz Y., Alkhalidi, Hala M.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 17.08.2023
• Subjects: 3D printing; Customized pharmaceuticals; Polypill; Customized pharmaceuticals; 3D printing; Polypill
• ISSN: 0014-3057; 1873-1945
• DOI: 10.1016/j.eurpolymj.2023.112240

Plausible features of personalized medicines by 3D technology. [Display omitted] •3DP technology is a new computer aided technology, highly efficient and cost effective.•3DP technology in the pharmaceutical era to customize medications with desired geometries and complex release profiles.•3DP technology used to prepare different structure dosages to tune specific attributes.•3DP technology used to design and fabricate novel, complex drugs as well as combine multiple active pharmaceutical ingredients (API). 3DP is a computer-aided designing with the interesting innovation of prototyping layer-by-layer, creating 3D articles as digital blueprints to accomplish unequaled gracefulness, time protection, and extraordinary assembling ability of pharmaceutical dosage forms. 3D printing technology offers a novel approach for the fabrication of personalized and customized pharmaceuticals. This emerging field often referred to as “pharmaceutical 3D printing” or “3D-printed medications,” has the potential to revolutionize the way medications are manufactured and administered. By using different method like binder jetting, solid-state extrusion (SSE), hot melt extrusion (HME), digital light processing (DLP), stereo lithography apparatus (SLA), selective laser sintering (SLS), vat polymerization, and fused deposition displaying (FDM). 3DP is a unique technology that was first conceptualized in 1986 by Charles Hull in field of pharmaceutical, medical. It is used to create on-demand, customizable, low volume/high volume, intricate yet more precise, and efficacious medications with desired geometries, hues, flavors, dosages, administration routes, and complex release profiles that has the capacity to improve compliance. In this review we focus on traditional methods of 3DP producing medicine, it does not require a large production area. Instead, medicines can be produced in a pharmacy, in a hospital or even in a patient’s home by using specialized 3D printer that uses a specialized ink that contains a mixture of active ingredients and excipients. A significant accomplishment was made in this field in 2015 when Spritam, an epileptic medic, was the first Food and Drug Administration(FDA) approved 3D printed medicine. Moreover, 3DP has enormous potential so that it can be utilized in a vast scope of the medical field and robotics. In the future, 3DP technology the potential to revolutionize organ transplantation and tissue repair therapies. On-demand 3D production of medicines will also be cost-effective. 3DP plays a unique role in customized medicine or drugs, nutritional products, and organs, Researcher solve the problem facing during the integration of 3D printing with tissue engineering.