Cephaloliverols A and B, two sterol-hybrid meroterpenoids from Cephalotaxus oliveri

Cephaloliverols A (1) and B (2), two meroterpenoids based on a sterol and an abietane diterpene possessing a dioxane ring, were isolated from the twigs and leaves of Cephatotaxus oliveri. Their structures were established by spectroscopic analysis and quantum chemical calculation. 1 and 2 represent...

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Published inOrganic & biomolecular chemistry Vol. 20; no. 18; pp. 3712 - 3716
Main Authors Jiang, Chunyu, Fan, Xiaojie, Zou, Deli, Li, Zhanlin, Han, Tong, Lin, Bin, Hua, Huiming, Li, Dahong
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 11.05.2022
Royal Society of Chemistry
Subjects
Abietanes
Cephalotaxus
Cephalotaxus - chemistry
Chemistry
Chemistry, Organic
Lipopolysaccharides
Macrophages
Molecular Structure
Physical Sciences
Plant Leaves - chemistry
Quantum chemistry
Science & Technology
Sterols
Sterols - pharmacology
BARK
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Summary:Cephaloliverols A (1) and B (2), two meroterpenoids based on a sterol and an abietane diterpene possessing a dioxane ring, were isolated from the twigs and leaves of Cephatotaxus oliveri. Their structures were established by spectroscopic analysis and quantum chemical calculation. 1 and 2 represent the first sterol-hybrid meroditerpenoids. The two compounds and their precursors decreased NO production in a dose-dependent manner in LPS-stimulated RAW 264.7 macrophages.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob00370h