Palladium-catalyzed synthesis of 5-amino-1,2,4-oxadiazoles via isocyanide insertion

A convenient and efficient palladium-catalyzed approach has been developed for the synthesis of 5-amino-1,2,4-oxadiazoles from amidoximes and isocyanides. Various 5-amino-1,2,4-oxadiazoles were obtained in moderate to high yields under mild conditions. The key to the success of this strategy involve...

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Published inOrganic & biomolecular chemistry Vol. 18; no. 26; pp. 4936 - 4940
Main Authors Wang, Xu, Fu, Jin-Ping, Xie, Jia-Xing, Teng, Qing-Hu, Tang, Hai-Tao, Pan, Ying-Ming
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 08.07.2020
Royal Society of Chemistry
Subjects
Chemical synthesis
Chemistry
Chemistry, Organic
Insertion
Oxadiazoles
Palladium
Physical Sciences
Science & Technology
FUNCTIONALIZATION
ANNULATION
DISCOVERY
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Summary:A convenient and efficient palladium-catalyzed approach has been developed for the synthesis of 5-amino-1,2,4-oxadiazoles from amidoximes and isocyanides. Various 5-amino-1,2,4-oxadiazoles were obtained in moderate to high yields under mild conditions. The key to the success of this strategy involves new C-N bond and C-O bond formation via palladium-catalyzed isocyanide insertion.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1477-0520
1477-0539
DOI:10.1039/d0ob01092h