Puerarin suppression of Aβ1-42 -induced primary cortical neuron death is largely dependent on ERβ
Highlights • Puerarin suppresses Aβ1-42 -induced decrease in neuron numbers and neurite growth. • Puerarin protection of the neuron is dependent on the activity of estrogen receptor. • Puerarin suppresses Aβ1-42 -induced caspases cleavage via ERβ. • Puerarin up-regulates the expression of ERβ but no...
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Published in | Brain research Vol. 1657; pp. 87 - 94 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier B.V
15.02.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • Puerarin suppresses Aβ1-42 -induced decrease in neuron numbers and neurite growth. • Puerarin protection of the neuron is dependent on the activity of estrogen receptor. • Puerarin suppresses Aβ1-42 -induced caspases cleavage via ERβ. • Puerarin up-regulates the expression of ERβ but not ERα. |
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ISSN: | 0006-8993 1872-6240 |
DOI: | 10.1016/j.brainres.2016.11.023 |