Puerarin suppression of Aβ1-42 -induced primary cortical neuron death is largely dependent on ERβ

Highlights • Puerarin suppresses Aβ1-42 -induced decrease in neuron numbers and neurite growth. • Puerarin protection of the neuron is dependent on the activity of estrogen receptor. • Puerarin suppresses Aβ1-42 -induced caspases cleavage via ERβ. • Puerarin up-regulates the expression of ERβ but no...

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Bibliographic Details
Published inBrain research Vol. 1657; pp. 87 - 94
Main Authors Li, Li, Xue, Zuguang, Chen, Lei, Chen, Xueyu, Wang, Heshuang, Wang, Xiaobo
Format Journal Article
LanguageEnglish
Published Elsevier B.V 15.02.2017
Subjects
Alzheimer’s disease
Amyloid beta
Cortical neuron
Estrogen receptor
Neurology
Neuroprotection
Puerarin
Estrogen receptor
Neuroprotection
Cortical neuron
Alzheimer’s Disease
Amyloid beta
Puerarin
Alzheimer’s disease
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Summary:Highlights • Puerarin suppresses Aβ1-42 -induced decrease in neuron numbers and neurite growth. • Puerarin protection of the neuron is dependent on the activity of estrogen receptor. • Puerarin suppresses Aβ1-42 -induced caspases cleavage via ERβ. • Puerarin up-regulates the expression of ERβ but not ERα.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2016.11.023