A near-infrared xanthene fluorescence probe for monitoring peroxynitrite in living cells and mouse inflammation model

Peroxynitrite (ONOO-) plays important roles in the regulation of many physiological and pathological processes, and an increase in its levels is related to numerous diseases. Thus, accurate detection of ONOO- in physiological conditions is imperative for elucidating its functions. However, studies o...

Full description

Saved in:
Bibliographic Details
Published inAnalyst (London) Vol. 143; no. 22; pp. 5512 - 5519
Main Authors Wu, Yongquan, Shi, Aiping, Li, Yuanyan, Zeng, Hong, Chen, Xiaoyong, Wu, Jie, Fan, Xiaolin
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 05.11.2018
Subjects
Animals
Cells (biology)
Fluorescence
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent Dyes - toxicity
Fluorescent indicators
Humans
In vivo methods and tests
Inflammation - metabolism
Limit of Detection
MCF-7 Cells
Mice
Peroxynitrous Acid - analysis
Phosphinic Acids - chemical synthesis
Phosphinic Acids - chemistry
Phosphinic Acids - toxicity
Physiology
RAW 264.7 Cells
Selectivity
Spectrometry, Fluorescence - methods
Xanthenes - chemical synthesis
Xanthenes - chemistry
Xanthenes - toxicity
Online AccessGet full text

Cover

Abstract Peroxynitrite (ONOO-) plays important roles in the regulation of many physiological and pathological processes, and an increase in its levels is related to numerous diseases. Thus, accurate detection of ONOO- in physiological conditions is imperative for elucidating its functions. However, studies on high signal-to-noise-ratio (SNR) fluorescence imaging of ONOO-in vivo for its detection are currently lacking. Thus, a novel NIR xanthene fluorescence probe (NOF2) for the endogenous detection of ONOO- is designed and synthesized. The fluorescence of the NOF2 probe is pre-quenched by the hydroxyl protection group of diphenyl phosphinate. Additionally, the NOF2 probe exhibits good selectivity and sensitivity for ONOO- with a low detection limit of 0.40 μM. Importantly, the NOF2 probe displays good performances for the detection of endogenous ONOO- not only in living cells but also in a mouse inflammation model. This demonstrates its great potential for applications involving the detection of ONOO- both in vitro and in vivo to explore the roles of ONOO- in different physiological systems.
AbstractList Peroxynitrite (ONOO-) plays important roles in the regulation of many physiological and pathological processes, and an increase in its levels is related to numerous diseases. Thus, accurate detection of ONOO- in physiological conditions is imperative for elucidating its functions. However, studies on high signal-to-noise-ratio (SNR) fluorescence imaging of ONOO-in vivo for its detection are currently lacking. Thus, a novel NIR xanthene fluorescence probe (NOF2) for the endogenous detection of ONOO- is designed and synthesized. The fluorescence of the NOF2 probe is pre-quenched by the hydroxyl protection group of diphenyl phosphinate. Additionally, the NOF2 probe exhibits good selectivity and sensitivity for ONOO- with a low detection limit of 0.40 μM. Importantly, the NOF2 probe displays good performances for the detection of endogenous ONOO- not only in living cells but also in a mouse inflammation model. This demonstrates its great potential for applications involving the detection of ONOO- both in vitro and in vivo to explore the roles of ONOO- in different physiological systems.
Peroxynitrite (ONOO − ) plays important roles in the regulation of many physiological and pathological processes, and an increase in its levels is related to numerous diseases. Thus, accurate detection of ONOO − in physiological conditions is imperative for elucidating its functions. However, studies on high signal-to-noise-ratio (SNR) fluorescence imaging of ONOO − in vivo for its detection are currently lacking. Thus, a novel NIR xanthene fluorescence probe (NOF2) for the endogenous detection of ONOO − is designed and synthesized. The fluorescence of the NOF2 probe is pre-quenched by the hydroxyl protection group of diphenyl phosphinate. Additionally, the NOF2 probe exhibits good selectivity and sensitivity for ONOO − with a low detection limit of 0.40 μM. Importantly, the NOF2 probe displays good performances for the detection of endogenous ONOO − not only in living cells but also in a mouse inflammation model. This demonstrates its great potential for applications involving the detection of ONOO − both in vitro and in vivo to explore the roles of ONOO − in different physiological systems.
Peroxynitrite (ONOO−) plays important roles in the regulation of many physiological and pathological processes, and an increase in its levels is related to numerous diseases. Thus, accurate detection of ONOO− in physiological conditions is imperative for elucidating its functions. However, studies on high signal-to-noise-ratio (SNR) fluorescence imaging of ONOO−in vivo for its detection are currently lacking. Thus, a novel NIR xanthene fluorescence probe (NOF2) for the endogenous detection of ONOO− is designed and synthesized. The fluorescence of the NOF2 probe is pre-quenched by the hydroxyl protection group of diphenyl phosphinate. Additionally, the NOF2 probe exhibits good selectivity and sensitivity for ONOO− with a low detection limit of 0.40 μM. Importantly, the NOF2 probe displays good performances for the detection of endogenous ONOO− not only in living cells but also in a mouse inflammation model. This demonstrates its great potential for applications involving the detection of ONOO− both in vitro and in vivo to explore the roles of ONOO− in different physiological systems.
Author Wu, Jie
Li, Yuanyan
Fan, Xiaolin
Wu, Yongquan
Zeng, Hong
Shi, Aiping
Chen, Xiaoyong
Author_xml – sequence: 1
  givenname: Yongquan
  surname: Wu
  fullname: Wu, Yongquan
  email: wyq@gnnu.edu.cn, fanxl2013@gnnu.cn
  organization: School of Chemistry and Chemical Engineering & Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou Jiangxi 341000, P. R. China. wyq@gnnu.edu.cn fanxl2013@gnnu.cn
– sequence: 2
  givenname: Aiping
  surname: Shi
  fullname: Shi, Aiping
– sequence: 3
  givenname: Yuanyan
  surname: Li
  fullname: Li, Yuanyan
– sequence: 4
  givenname: Hong
  surname: Zeng
  fullname: Zeng, Hong
– sequence: 5
  givenname: Xiaoyong
  surname: Chen
  fullname: Chen, Xiaoyong
– sequence: 6
  givenname: Jie
  surname: Wu
  fullname: Wu, Jie
– sequence: 7
  givenname: Xiaolin
  surname: Fan
  fullname: Fan, Xiaolin
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30295297$$D View this record in MEDLINE/PubMed
BookMark eNpdkU9LxDAQxYMouqte_AAS8CJCdZJs2uS4LP4D0YueS9pONdIma9KKfntTVz14GubNjzePmTnZdt4hIUcMzhkIfVEr44AxKMwWmTGRLzIpudomMwAQGc_lYo_MY3xNLQMJu2RPANeS62JGxiV1aEJmXRtMwIZ-GDe8oEPadqMPGGt0NdJ18FWSfKC9d3bwwbpnusbgPz5TG-yA1Dra2fdJr7HrIjWuSfAYp0nbmb43g_UuSQ12B2SnNV3Ew5-6T56uLh9XN9ndw_XtanmX1YLJIZOLOi-U0bksGtQVNIxLnrdMs4YZo5kBqYWqBRfQSFQSlBbCtKBFVVWglNgnpxvflP9txDiUvY1TPOMwRSs5YwWTheAyoSf_0Fc_BpfSJYrrHNKWyfBsQ9XBxxiwLdfB9iZ8lgzK6RnlSi3vv5-xTPDxj-VY9dj8ob_XF1_KzIah
CitedBy_id crossref_primary_10_1016_j_aca_2024_342768
crossref_primary_10_1021_acs_analchem_0c05118
crossref_primary_10_1021_acsami_9b18135
crossref_primary_10_1016_j_saa_2022_121264
crossref_primary_10_1039_C8AY02632G
crossref_primary_10_1002_chem_202002772
crossref_primary_10_1021_acs_analchem_9b03937
crossref_primary_10_1002_adhm_202303710
crossref_primary_10_1016_j_saa_2021_119502
crossref_primary_10_1016_j_saa_2021_120568
crossref_primary_10_1016_j_snb_2021_129603
crossref_primary_10_3390_chemosensors11050286
crossref_primary_10_1016_j_dyepig_2022_110341
crossref_primary_10_1016_j_ccr_2022_214848
crossref_primary_10_1016_j_snb_2020_127890
crossref_primary_10_1039_C9SC03798E
crossref_primary_10_3390_chemosensors11110555
crossref_primary_10_1016_j_saa_2020_118073
crossref_primary_10_1002_slct_202203377
crossref_primary_10_1016_j_saa_2019_117762
crossref_primary_10_1021_acs_analchem_9b04990
crossref_primary_10_1016_j_ab_2023_115114
crossref_primary_10_1016_j_jhazmat_2022_128527
crossref_primary_10_2174_1570179419666220308145901
crossref_primary_10_1021_acs_chemrestox_4c00023
crossref_primary_10_1016_j_dyepig_2023_111404
crossref_primary_10_1021_acsami_3c09320
crossref_primary_10_1021_acssensors_0c02343
crossref_primary_10_1021_acssensors_2c01857
crossref_primary_10_1039_D2RA04549D
crossref_primary_10_1002_VIW_20200025
crossref_primary_10_1021_acs_analchem_0c02509
crossref_primary_10_1039_C9AN01934K
crossref_primary_10_1016_j_dyepig_2021_109727
Cites_doi 10.1021/acs.chemrev.7b00568
10.1039/C7CC04093H
10.1021/acs.analchem.7b01671
10.1021/ol4017222
10.1021/acs.analchem.7b00503
10.1021/acs.analchem.8b00198
10.1039/C7SC00303J
10.1002/anie.201612020
10.1038/86707
10.1021/jacs.6b10508
10.1016/j.cbpa.2003.08.007
10.1038/nrd2222
10.1039/C7TB00703E
10.1021/acs.bioconjchem.5b00259
10.3164/jcbn.R09-66
10.1021/ja209292b
10.1016/j.bios.2017.05.054
10.1016/j.biomaterials.2013.08.081
10.1021/acs.accounts.7b00087
10.1021/cr2004103
10.1039/C7CC07845E
10.1016/j.snb.2016.06.054
10.1021/ja401360a
10.1002/chem.200600497
10.1021/jacs.6b12845
10.1021/cb800279q
10.1021/ja305046u
10.1074/jbc.R113.472936
10.1021/ac902821v
10.1016/j.snb.2017.10.163
10.1021/ja202582x
10.1039/C6CS00192K
10.1039/C7TB02615C
10.1016/j.freeradbiomed.2010.04.010
10.1039/C3CS60271K
10.1039/c0cc03999c
10.1152/physrev.00029.2006
10.1039/C7TB01560G
10.1002/adma.201601214
10.1039/C7TB03199H
10.1016/j.jphotochem.2017.09.057
10.1021/acs.analchem.7b02059
10.1039/b802497a
10.1038/320454a0
10.1016/S0076-6879(99)01101-5
10.1021/acschembio.7b00159
10.1016/j.bbrc.2017.10.123
10.1021/ol800591u
10.1039/C5CC09976E
10.1016/j.bios.2017.01.027
10.1016/j.talanta.2018.01.028
10.1042/bj3240001
10.1021/acs.jpca.7b10716
10.1016/j.bios.2016.10.060
10.1016/j.bios.2014.08.089
10.1016/j.freeradbiomed.2016.08.033
10.1021/acs.analchem.6b01135
10.1002/adma.201602939
10.1073/pnas.87.4.1620
10.1039/C8SC00733K
ContentType Journal Article
Copyright Copyright Royal Society of Chemistry 2018
Copyright_xml – notice: Copyright Royal Society of Chemistry 2018
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7SR
7U5
8BQ
8FD
JG9
L7M
7X8
DOI 10.1039/c8an01107a
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Engineered Materials Abstracts
Solid State and Superconductivity Abstracts
METADEX
Technology Research Database
Materials Research Database
Advanced Technologies Database with Aerospace
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Materials Research Database
Engineered Materials Abstracts
Solid State and Superconductivity Abstracts
Technology Research Database
Advanced Technologies Database with Aerospace
METADEX
MEDLINE - Academic
DatabaseTitleList MEDLINE
CrossRef
MEDLINE - Academic
Materials Research Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1364-5528
EndPage 5519
ExternalDocumentID 10_1039_C8AN01107A
30295297
Genre Journal Article
GroupedDBID ---
-JG
-~X
.HR
0-7
0R~
23M
2WC
4.4
5RE
705
70~
7~J
AAEMU
AAIWI
AAJAE
AANOJ
AAWGC
AAXHV
AAXPP
ABASK
ABDVN
ABEMK
ABGFH
ABJNI
ABOCM
ABPDG
ABRYZ
ABXOH
ACGFS
ACIWK
ACLDK
ADMRA
ADSRN
AEFDR
AENEX
AENGV
AESAV
AETIL
AFLYV
AFOGI
AFVBQ
AGEGJ
AGRSR
AGSTE
AHGCF
ALMA_UNASSIGNED_HOLDINGS
ANUXI
APEMP
ASKNT
AUDPV
AZFZN
BLAPV
BSQNT
C6K
CGR
COF
CS3
CUY
CVF
EBS
ECGLT
ECM
EE0
EF-
EIF
EJD
F5P
GGIMP
GNO
H13
HZ~
H~N
IDZ
J3I
M4U
N9A
NPM
O9-
P2P
R7B
R7E
RAOCF
RCNCU
RIG
RPMJG
RRA
RRC
RSCEA
SKM
SKR
SKZ
SLC
SLF
TN5
UPT
VH6
WH7
~02
AAYXX
CITATION
7SR
7U5
8BQ
8FD
JG9
L7M
7X8
ID FETCH-LOGICAL-c315t-54c678a9657de9b0d12526f191d1aa91a05938c3230d5e8508933af093bbb0883
ISSN 0003-2654
IngestDate Fri Aug 16 21:43:24 EDT 2024
Thu Oct 10 19:21:43 EDT 2024
Fri Aug 23 00:43:08 EDT 2024
Sat Sep 28 08:39:22 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 22
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c315t-54c678a9657de9b0d12526f191d1aa91a05938c3230d5e8508933af093bbb0883
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0001-5423-1195
PMID 30295297
PQID 2129603238
PQPubID 2047505
PageCount 8
ParticipantIDs proquest_miscellaneous_2117157325
proquest_journals_2129603238
crossref_primary_10_1039_C8AN01107A
pubmed_primary_30295297
PublicationCentury 2000
PublicationDate 2018-Nov-05
PublicationDateYYYYMMDD 2018-11-05
PublicationDate_xml – month: 11
  year: 2018
  text: 2018-Nov-05
  day: 05
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Analyst (London)
PublicationTitleAlternate Analyst
PublicationYear 2018
Publisher Royal Society of Chemistry
Publisher_xml – name: Royal Society of Chemistry
References Li (C8AN01107A-(cit36)/*[position()=1]) 2017; 8
Zhang (C8AN01107A-(cit56)/*[position()=1]) 2016; 52
Imaram (C8AN01107A-(cit14)/*[position()=1]) 2010; 49
Guo (C8AN01107A-(cit49)/*[position()=1]) 2014; 43
Kim (C8AN01107A-(cit54)/*[position()=1]) 2008; 37
Guo (C8AN01107A-(cit32)/*[position()=1]) 2018; 6
Zhang (C8AN01107A-(cit52)/*[position()=1]) 2012; 134
Xuan (C8AN01107A-(cit18)/*[position()=1]) 2016; 27
Xia (C8AN01107A-(cit23)/*[position()=1]) 2018; 355
Chen (C8AN01107A-(cit4)/*[position()=1]) 2016; 45
Li (C8AN01107A-(cit29)/*[position()=1]) 2017; 89
Ferrer-Sueta (C8AN01107A-(cit8)/*[position()=1]) 2009; 4
Murale (C8AN01107A-(cit55)/*[position()=1]) 2013; 15
Yuan (C8AN01107A-(cit58)/*[position()=1]) 2012; 134
Nagano (C8AN01107A-(cit9)/*[position()=1]) 2009; 45
Gryglewski (C8AN01107A-(cit1)/*[position()=1]) 1986; 320
Wang (C8AN01107A-(cit60)/*[position()=1]) 2008; 10
Szabo (C8AN01107A-(cit7)/*[position()=1]) 2007; 6
Wu (C8AN01107A-(cit16)/*[position()=1]) 2018; 181
Song (C8AN01107A-(cit30)/*[position()=1]) 2016; 28
Li (C8AN01107A-(cit35)/*[position()=1]) 2017; 89
Li (C8AN01107A-(cit33)/*[position()=1]) 2018; 122
Rios (C8AN01107A-(cit37)/*[position()=1]) 2016; 101
Frangioni (C8AN01107A-(cit43)/*[position()=1]) 2003; 7
Radi (C8AN01107A-(cit3)/*[position()=1]) 2013; 288
Pacher (C8AN01107A-(cit6)/*[position()=1]) 2007; 87
Yue (C8AN01107A-(cit22)/*[position()=1]) 2017; 139
Xu (C8AN01107A-(cit57)/*[position()=1]) 2007; 13
Kong (C8AN01107A-(cit50)/*[position()=1]) 2016; 88
Yuan (C8AN01107A-(cit53)/*[position()=1]) 2013; 34
Fang (C8AN01107A-(cit46)/*[position()=1]) 2017; 53
Chen (C8AN01107A-(cit51)/*[position()=1]) 2011; 47
Tong (C8AN01107A-(cit47)/*[position()=1]) 2018; 6
Jiang (C8AN01107A-(cit15)/*[position()=1]) 2018; 261
Zhu (C8AN01107A-(cit39)/*[position()=1]) 2017; 97
Yang (C8AN01107A-(cit44)/*[position()=1]) 2013; 113
Dong (C8AN01107A-(cit45)/*[position()=1]) 2017; 5
Cheng (C8AN01107A-(cit10)/*[position()=1]) 2017; 89
Zhou (C8AN01107A-(cit38)/*[position()=1]) 2015; 64
Beckman (C8AN01107A-(cit59)/*[position()=1]) 1990; 87
Moison (C8AN01107A-(cit21)/*[position()=1]) 2017; 12
Becker (C8AN01107A-(cit17)/*[position()=1]) 2001; 19
Sun (C8AN01107A-(cit31)/*[position()=1]) 2017; 494
Dean (C8AN01107A-(cit2)/*[position()=1]) 1997; 324
Peng (C8AN01107A-(cit11)/*[position()=1]) 2017; 56
Cheng (C8AN01107A-(cit26)/*[position()=1]) 2017; 139
Li (C8AN01107A-(cit34)/*[position()=1]) 2018; 90
Wu (C8AN01107A-(cit41)/*[position()=1]) 2017; 90
Ferrer-Sueta (C8AN01107A-(cit5)/*[position()=1]) 2018; 118
Dong (C8AN01107A-(cit19)/*[position()=1]) 2016; 28
Sedgwick (C8AN01107A-(cit27)/*[position()=1]) 2017; 53
Yu (C8AN01107A-(cit24)/*[position()=1]) 2011; 133
Lee (C8AN01107A-(cit48)/*[position()=1]) 2018; 6
Viera (C8AN01107A-(cit12)/*[position()=1]) 1999; 301
Chen (C8AN01107A-(cit20)/*[position()=1]) 2017; 50
Hulvey (C8AN01107A-(cit13)/*[position()=1]) 2010; 82
Zhang (C8AN01107A-(cit42)/*[position()=1]) 2016; 237
Sedgwick (C8AN01107A-(cit28)/*[position()=1]) 2018; 9
Palanisamy (C8AN01107A-(cit40)/*[position()=1]) 2017; 91
Yu (C8AN01107A-(cit25)/*[position()=1]) 2013; 135
References_xml – volume: 118
  start-page: 462
  year: 2018
  ident: C8AN01107A-(cit5)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/acs.chemrev.7b00568
  contributor:
    fullname: Ferrer-Sueta
– volume: 53
  start-page: 8759
  year: 2017
  ident: C8AN01107A-(cit46)/*[position()=1]
  publication-title: Chem. Commun.
  doi: 10.1039/C7CC04093H
  contributor:
    fullname: Fang
– volume: 89
  start-page: 7693
  year: 2017
  ident: C8AN01107A-(cit10)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.7b01671
  contributor:
    fullname: Cheng
– volume: 15
  start-page: 3946
  year: 2013
  ident: C8AN01107A-(cit55)/*[position()=1]
  publication-title: Org. Lett.
  doi: 10.1021/ol4017222
  contributor:
    fullname: Murale
– volume: 89
  start-page: 5519
  year: 2017
  ident: C8AN01107A-(cit35)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.7b00503
  contributor:
    fullname: Li
– volume: 90
  start-page: 4167
  year: 2018
  ident: C8AN01107A-(cit34)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.8b00198
  contributor:
    fullname: Li
– volume: 8
  start-page: 4006
  year: 2017
  ident: C8AN01107A-(cit36)/*[position()=1]
  publication-title: Chem. Sci.
  doi: 10.1039/C7SC00303J
  contributor:
    fullname: Li
– volume: 56
  start-page: 4165
  year: 2017
  ident: C8AN01107A-(cit11)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.201612020
  contributor:
    fullname: Peng
– volume: 19
  start-page: 327
  year: 2001
  ident: C8AN01107A-(cit17)/*[position()=1]
  publication-title: Nat. Biotechnol.
  doi: 10.1038/86707
  contributor:
    fullname: Becker
– volume: 139
  start-page: 285
  year: 2017
  ident: C8AN01107A-(cit26)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.6b10508
  contributor:
    fullname: Cheng
– volume: 7
  start-page: 626
  year: 2003
  ident: C8AN01107A-(cit43)/*[position()=1]
  publication-title: Curr. Opin. Chem. Biol.
  doi: 10.1016/j.cbpa.2003.08.007
  contributor:
    fullname: Frangioni
– volume: 6
  start-page: 662
  year: 2007
  ident: C8AN01107A-(cit7)/*[position()=1]
  publication-title: Nat. Rev. Drug Discovery
  doi: 10.1038/nrd2222
  contributor:
    fullname: Szabo
– volume: 5
  start-page: 5218
  year: 2017
  ident: C8AN01107A-(cit45)/*[position()=1]
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C7TB00703E
  contributor:
    fullname: Dong
– volume: 27
  start-page: 302
  year: 2016
  ident: C8AN01107A-(cit18)/*[position()=1]
  publication-title: Bioconjugate Chem.
  doi: 10.1021/acs.bioconjchem.5b00259
  contributor:
    fullname: Xuan
– volume: 45
  start-page: 111
  year: 2009
  ident: C8AN01107A-(cit9)/*[position()=1]
  publication-title: J. Clin. Biochem. Nutr.
  doi: 10.3164/jcbn.R09-66
  contributor:
    fullname: Nagano
– volume: 134
  start-page: 1200
  year: 2012
  ident: C8AN01107A-(cit58)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja209292b
  contributor:
    fullname: Yuan
– volume: 97
  start-page: 150
  year: 2017
  ident: C8AN01107A-(cit39)/*[position()=1]
  publication-title: Biosens. Bioelectron.
  doi: 10.1016/j.bios.2017.05.054
  contributor:
    fullname: Zhu
– volume: 34
  start-page: 9566
  year: 2013
  ident: C8AN01107A-(cit53)/*[position()=1]
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.08.081
  contributor:
    fullname: Yuan
– volume: 50
  start-page: 1410
  year: 2017
  ident: C8AN01107A-(cit20)/*[position()=1]
  publication-title: Acc. Chem. Res.
  doi: 10.1021/acs.accounts.7b00087
  contributor:
    fullname: Chen
– volume: 113
  start-page: 192
  year: 2013
  ident: C8AN01107A-(cit44)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/cr2004103
  contributor:
    fullname: Yang
– volume: 53
  start-page: 12822
  year: 2017
  ident: C8AN01107A-(cit27)/*[position()=1]
  publication-title: Chem. Commun.
  doi: 10.1039/C7CC07845E
  contributor:
    fullname: Sedgwick
– volume: 237
  start-page: 67
  year: 2016
  ident: C8AN01107A-(cit42)/*[position()=1]
  publication-title: Sens. Actuators, B
  doi: 10.1016/j.snb.2016.06.054
  contributor:
    fullname: Zhang
– volume: 135
  start-page: 7674
  year: 2013
  ident: C8AN01107A-(cit25)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja401360a
  contributor:
    fullname: Yu
– volume: 13
  start-page: 1411
  year: 2007
  ident: C8AN01107A-(cit57)/*[position()=1]
  publication-title: Chem. – Eur. J.
  doi: 10.1002/chem.200600497
  contributor:
    fullname: Xu
– volume: 139
  start-page: 3181
  year: 2017
  ident: C8AN01107A-(cit22)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.6b12845
  contributor:
    fullname: Yue
– volume: 4
  start-page: 161
  year: 2009
  ident: C8AN01107A-(cit8)/*[position()=1]
  publication-title: ACS Chem. Biol.
  doi: 10.1021/cb800279q
  contributor:
    fullname: Ferrer-Sueta
– volume: 134
  start-page: 18479
  year: 2012
  ident: C8AN01107A-(cit52)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja305046u
  contributor:
    fullname: Zhang
– volume: 288
  start-page: 26464
  year: 2013
  ident: C8AN01107A-(cit3)/*[position()=1]
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.R113.472936
  contributor:
    fullname: Radi
– volume: 82
  start-page: 1608
  year: 2010
  ident: C8AN01107A-(cit13)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/ac902821v
  contributor:
    fullname: Hulvey
– volume: 261
  start-page: 115
  year: 2018
  ident: C8AN01107A-(cit15)/*[position()=1]
  publication-title: Sens. Actuators, B
  doi: 10.1016/j.snb.2017.10.163
  contributor:
    fullname: Jiang
– volume: 133
  start-page: 11030
  year: 2011
  ident: C8AN01107A-(cit24)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja202582x
  contributor:
    fullname: Yu
– volume: 45
  start-page: 2976
  year: 2016
  ident: C8AN01107A-(cit4)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/C6CS00192K
  contributor:
    fullname: Chen
– volume: 6
  start-page: 580
  year: 2018
  ident: C8AN01107A-(cit32)/*[position()=1]
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C7TB02615C
  contributor:
    fullname: Guo
– volume: 49
  start-page: 275
  year: 2010
  ident: C8AN01107A-(cit14)/*[position()=1]
  publication-title: Free Radicals Biol. Med.
  doi: 10.1016/j.freeradbiomed.2010.04.010
  contributor:
    fullname: Imaram
– volume: 43
  start-page: 16
  year: 2014
  ident: C8AN01107A-(cit49)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/C3CS60271K
  contributor:
    fullname: Guo
– volume: 47
  start-page: 3135
  year: 2011
  ident: C8AN01107A-(cit51)/*[position()=1]
  publication-title: Chem. Commun.
  doi: 10.1039/c0cc03999c
  contributor:
    fullname: Chen
– volume: 87
  start-page: 315
  year: 2007
  ident: C8AN01107A-(cit6)/*[position()=1]
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00029.2006
  contributor:
    fullname: Pacher
– volume: 6
  start-page: 2541
  year: 2018
  ident: C8AN01107A-(cit48)/*[position()=1]
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C7TB01560G
  contributor:
    fullname: Lee
– volume: 28
  start-page: 7249
  year: 2016
  ident: C8AN01107A-(cit30)/*[position()=1]
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201601214
  contributor:
    fullname: Song
– volume: 6
  start-page: 1791
  year: 2018
  ident: C8AN01107A-(cit47)/*[position()=1]
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C7TB03199H
  contributor:
    fullname: Tong
– volume: 355
  start-page: 165
  year: 2018
  ident: C8AN01107A-(cit23)/*[position()=1]
  publication-title: J. Photochem. Photobiol., A
  doi: 10.1016/j.jphotochem.2017.09.057
  contributor:
    fullname: Xia
– volume: 89
  start-page: 8496
  year: 2017
  ident: C8AN01107A-(cit29)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.7b02059
  contributor:
    fullname: Li
– volume: 37
  start-page: 1453
  year: 2008
  ident: C8AN01107A-(cit54)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/b802497a
  contributor:
    fullname: Kim
– volume: 320
  start-page: 454
  year: 1986
  ident: C8AN01107A-(cit1)/*[position()=1]
  publication-title: Nature
  doi: 10.1038/320454a0
  contributor:
    fullname: Gryglewski
– volume: 301
  start-page: 373
  year: 1999
  ident: C8AN01107A-(cit12)/*[position()=1]
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(99)01101-5
  contributor:
    fullname: Viera
– volume: 12
  start-page: 928
  year: 2017
  ident: C8AN01107A-(cit21)/*[position()=1]
  publication-title: ACS Chem. Biol.
  doi: 10.1021/acschembio.7b00159
  contributor:
    fullname: Moison
– volume: 494
  start-page: 518
  year: 2017
  ident: C8AN01107A-(cit31)/*[position()=1]
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2017.10.123
  contributor:
    fullname: Sun
– volume: 10
  start-page: 2071
  year: 2008
  ident: C8AN01107A-(cit60)/*[position()=1]
  publication-title: Org. Lett.
  doi: 10.1021/ol800591u
  contributor:
    fullname: Wang
– volume: 52
  start-page: 2679
  year: 2016
  ident: C8AN01107A-(cit56)/*[position()=1]
  publication-title: Chem. Commun.
  doi: 10.1039/C5CC09976E
  contributor:
    fullname: Zhang
– volume: 91
  start-page: 849
  year: 2017
  ident: C8AN01107A-(cit40)/*[position()=1]
  publication-title: Biosens. Bioelectron.
  doi: 10.1016/j.bios.2017.01.027
  contributor:
    fullname: Palanisamy
– volume: 181
  start-page: 239
  year: 2018
  ident: C8AN01107A-(cit16)/*[position()=1]
  publication-title: Talanta
  doi: 10.1016/j.talanta.2018.01.028
  contributor:
    fullname: Wu
– volume: 324
  start-page: 1
  year: 1997
  ident: C8AN01107A-(cit2)/*[position()=1]
  publication-title: Biochem. J.
  doi: 10.1042/bj3240001
  contributor:
    fullname: Dean
– volume: 122
  start-page: 217
  year: 2018
  ident: C8AN01107A-(cit33)/*[position()=1]
  publication-title: J. Phys. Chem. A
  doi: 10.1021/acs.jpca.7b10716
  contributor:
    fullname: Li
– volume: 90
  start-page: 501
  year: 2017
  ident: C8AN01107A-(cit41)/*[position()=1]
  publication-title: Biosens. Bioelectron.
  doi: 10.1016/j.bios.2016.10.060
  contributor:
    fullname: Wu
– volume: 64
  start-page: 285
  year: 2015
  ident: C8AN01107A-(cit38)/*[position()=1]
  publication-title: Biosens. Bioelectron.
  doi: 10.1016/j.bios.2014.08.089
  contributor:
    fullname: Zhou
– volume: 101
  start-page: 284
  year: 2016
  ident: C8AN01107A-(cit37)/*[position()=1]
  publication-title: Free Radicals Biol. Med.
  doi: 10.1016/j.freeradbiomed.2016.08.033
  contributor:
    fullname: Rios
– volume: 88
  start-page: 6450
  year: 2016
  ident: C8AN01107A-(cit50)/*[position()=1]
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.6b01135
  contributor:
    fullname: Kong
– volume: 28
  start-page: 8755
  year: 2016
  ident: C8AN01107A-(cit19)/*[position()=1]
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201602939
  contributor:
    fullname: Dong
– volume: 87
  start-page: 1620
  year: 1990
  ident: C8AN01107A-(cit59)/*[position()=1]
  publication-title: Proc. Nat. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.87.4.1620
  contributor:
    fullname: Beckman
– volume: 9
  start-page: 3672
  year: 2018
  ident: C8AN01107A-(cit28)/*[position()=1]
  publication-title: Chem. Sci.
  doi: 10.1039/C8SC00733K
  contributor:
    fullname: Sedgwick
SSID ssj0001050
Score 2.4662097
Snippet Peroxynitrite (ONOO-) plays important roles in the regulation of many physiological and pathological processes, and an increase in its levels is related to...
Peroxynitrite (ONOO − ) plays important roles in the regulation of many physiological and pathological processes, and an increase in its levels is related to...
Peroxynitrite (ONOO−) plays important roles in the regulation of many physiological and pathological processes, and an increase in its levels is related to...
SourceID proquest
crossref
pubmed
SourceType Aggregation Database
Index Database
StartPage 5512
SubjectTerms Animals
Cells (biology)
Fluorescence
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent Dyes - toxicity
Fluorescent indicators
Humans
In vivo methods and tests
Inflammation - metabolism
Limit of Detection
MCF-7 Cells
Mice
Peroxynitrous Acid - analysis
Phosphinic Acids - chemical synthesis
Phosphinic Acids - chemistry
Phosphinic Acids - toxicity
Physiology
RAW 264.7 Cells
Selectivity
Spectrometry, Fluorescence - methods
Xanthenes - chemical synthesis
Xanthenes - chemistry
Xanthenes - toxicity
Title A near-infrared xanthene fluorescence probe for monitoring peroxynitrite in living cells and mouse inflammation model
URI https://www.ncbi.nlm.nih.gov/pubmed/30295297
https://www.proquest.com/docview/2129603238
https://search.proquest.com/docview/2117157325
Volume 143
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwGLVge4AXxJ3CQEbwVgWSOE7ix6jqVFApD6Si8BI5tzFppFtJpI1fz7GdW6UhDV6ixnGcxt_x52PnuxDyVgSOhKC5JVKVwiwrU0tK17F8T0IZskByWzk4f1r5i7X3ccM3gymv9i6p03fZ72v9Sv5HqiiDXJWX7D9Itm8UBfgN-eIICeN4IxlH0wpAtdDUTtuRX6KbfkB5TcuzZrvTgZoy5QilDCqUOeFPPYC1xZ2KD355hdMdOKfa9Dg71VsLaiPfhG1WewLqSgnMGP9GkzZnTGdNSJN6nBek31j42mj1vq1OLpoBgl90EuFppFJmn_TWQLrsG6pdDTW_F0YNLbZtxXZvwgm1k575SF0Yfcp8z-K89f_uFK4JzNQiy7glt_oT_M0dzcU4FdfqeZupMKlZKCvFX4LRbNZ9wV99To7Xy2USzzfxbXLoQg9BAR5G8_jDsp-qQS7tLmYtE--H9vZZyl-WHpqCxPfJvXbtQCMDhAfkVlE9JHdmXcq-R6SJ6B4gaAcIOgYE1YCgAAQdAEH3AEFPK2oAQTUgKABBNSDoGBBUA-IxWR_P49nCavNqWBlzeG1xLwNFkcLnQV5gjOYgua5fYuWeO1IKDF4uWJgxrE5zXoSg8IIxWdqCpWmKWYk9IQfVtiqeEZr5KvyPzHjhC8_3cDsv8tzJ08DJecr8CXnT9WNybsKnJNrsgYlkFkYr3dvRhBx1XZy0w-tXAk6F1TX-RDghr_vL6FD13rIq8M6o4wQOD5jLJ-SpEU3_GGa7grsieH6Du1-QuwN8j8hBvWuKlyCbdfqqhcwftMyGWQ
link.rule.ids 315,783,787,27936,27937
linkProvider Royal Society of Chemistry
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+near-infrared+xanthene+fluorescence+probe+for+monitoring+peroxynitrite+in+living+cells+and+mouse+inflammation+model&rft.jtitle=Analyst+%28London%29&rft.au=Wu%2C+Yongquan&rft.au=Shi%2C+Aiping&rft.au=Li%2C+Yuanyan&rft.au=Zeng%2C+Hong&rft.date=2018-11-05&rft.eissn=1364-5528&rft.volume=143&rft.issue=22&rft.spage=5512&rft.epage=5519&rft_id=info:doi/10.1039%2Fc8an01107a&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-2654&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-2654&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-2654&client=summon