Evaluating the therapeutic efficacy of nano-drugs targeting epidermal growth factor receptor

Epidermal growth factor receptor (EGFR) targeted nano-drugs facilitate effective diagnosis and treatment of cancer. Herein, the therapeutic efficacy of nano-drugs targeting EGFR was evaluated from the perspective of cell entry efficiency and induced cell mechanical properties using force tracing and...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 58; no. 16; pp. 2726 - 2729
Main Authors Zhao, Jing, Li, Siying, Pang, Xuelei, Shan, Yuping
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 22.02.2022
Subjects
A549 Cells
Drugs
Epidermal growth factor
ErbB Receptors - antagonists & inhibitors
ErbB Receptors - metabolism
Growth factors
Humans
Mechanical properties
Nanoindentation
Nanoparticles - chemistry
Polyamines - chemistry
Polyamines - pharmacology
Protein Kinase Inhibitors - chemistry
Protein Kinase Inhibitors - pharmacology
Receptors
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Summary:Epidermal growth factor receptor (EGFR) targeted nano-drugs facilitate effective diagnosis and treatment of cancer. Herein, the therapeutic efficacy of nano-drugs targeting EGFR was evaluated from the perspective of cell entry efficiency and induced cell mechanical properties using force tracing and nano-indentation techniques at the single particle/cell level in real time.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc06754k